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Salivary cytokine profile in patients with oral lichen planus
BACKGROUND/PURPOSE: Oral lichen planus (OLP) is a chronic inflammatory lesion of oral mucosal, and its pathogenesis involves immune cell-mediated aberrances. However, the findings conflict with each other. This research aimed to comprehensively detect the salivary cytokine profile of patients with O...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Association for Dental Sciences of the Republic of China
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739733/ https://www.ncbi.nlm.nih.gov/pubmed/35028026 http://dx.doi.org/10.1016/j.jds.2021.06.013 |
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author | Zhu, Zheng-Da Ren, Xiao-Meng Zhou, Mi-Mi Chen, Qian-Ming Hua, Hong Li, Chun-Lei |
author_facet | Zhu, Zheng-Da Ren, Xiao-Meng Zhou, Mi-Mi Chen, Qian-Ming Hua, Hong Li, Chun-Lei |
author_sort | Zhu, Zheng-Da |
collection | PubMed |
description | BACKGROUND/PURPOSE: Oral lichen planus (OLP) is a chronic inflammatory lesion of oral mucosal, and its pathogenesis involves immune cell-mediated aberrances. However, the findings conflict with each other. This research aimed to comprehensively detect the salivary cytokine profile of patients with OLP. MATERIALS AND METHODS: The cohort included 60 OLP patients (30 reticular and 30 erosive), and 30 healthy controls, matched in age and sex. Human Cytokine/Chemokine Magnetic Bead Panel Kit (HCYTMAG-60K-PX41) was used to detect salivary inflammation-related cytokines. Rank sum test, group t-test, and ANOVA were used for data analysis in different groups. Moreover, Spearman's rank correlation analysis was used to analyze the correlation between salivary cytokine levels and OLP lesion severity. RESULTS: The levels of TNF-α, G-GSF, IL-1α, IL-1β and IL-8 were statistically significant higher in both erosive and reticular OLP patients than in the healthy group, while the IL-13 level was significantly lower. Particularly, the salivary TNF-α, GM-CSF, MIP-1α, MIP-1β, IL-1β, IL-6 and IL-8 levels were higher in erosive OLP group than other groups. Spearman's rank correlation analysis revealed that the salivary TNF-α, GM-CSF, MIP-1α, MIP-1β, IL-1β and IL-6 levels were positively correlated with OLP lesion severity. CONCLUSION: Imbalance of the Th1/Th2-mediated immune response contributes to OLP. Certain salivary cytokines, such as MIP-1α, MIP-1β, GM-CSF, and IL-6, are positively correlated with OLP severity, and they have a high potential as biomarkers to diagnose and predict OLP prognosis. |
format | Online Article Text |
id | pubmed-8739733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Association for Dental Sciences of the Republic of China |
record_format | MEDLINE/PubMed |
spelling | pubmed-87397332022-01-12 Salivary cytokine profile in patients with oral lichen planus Zhu, Zheng-Da Ren, Xiao-Meng Zhou, Mi-Mi Chen, Qian-Ming Hua, Hong Li, Chun-Lei J Dent Sci Original Article BACKGROUND/PURPOSE: Oral lichen planus (OLP) is a chronic inflammatory lesion of oral mucosal, and its pathogenesis involves immune cell-mediated aberrances. However, the findings conflict with each other. This research aimed to comprehensively detect the salivary cytokine profile of patients with OLP. MATERIALS AND METHODS: The cohort included 60 OLP patients (30 reticular and 30 erosive), and 30 healthy controls, matched in age and sex. Human Cytokine/Chemokine Magnetic Bead Panel Kit (HCYTMAG-60K-PX41) was used to detect salivary inflammation-related cytokines. Rank sum test, group t-test, and ANOVA were used for data analysis in different groups. Moreover, Spearman's rank correlation analysis was used to analyze the correlation between salivary cytokine levels and OLP lesion severity. RESULTS: The levels of TNF-α, G-GSF, IL-1α, IL-1β and IL-8 were statistically significant higher in both erosive and reticular OLP patients than in the healthy group, while the IL-13 level was significantly lower. Particularly, the salivary TNF-α, GM-CSF, MIP-1α, MIP-1β, IL-1β, IL-6 and IL-8 levels were higher in erosive OLP group than other groups. Spearman's rank correlation analysis revealed that the salivary TNF-α, GM-CSF, MIP-1α, MIP-1β, IL-1β and IL-6 levels were positively correlated with OLP lesion severity. CONCLUSION: Imbalance of the Th1/Th2-mediated immune response contributes to OLP. Certain salivary cytokines, such as MIP-1α, MIP-1β, GM-CSF, and IL-6, are positively correlated with OLP severity, and they have a high potential as biomarkers to diagnose and predict OLP prognosis. Association for Dental Sciences of the Republic of China 2022-01 2021-07-07 /pmc/articles/PMC8739733/ /pubmed/35028026 http://dx.doi.org/10.1016/j.jds.2021.06.013 Text en © 2021 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Zhu, Zheng-Da Ren, Xiao-Meng Zhou, Mi-Mi Chen, Qian-Ming Hua, Hong Li, Chun-Lei Salivary cytokine profile in patients with oral lichen planus |
title | Salivary cytokine profile in patients with oral lichen planus |
title_full | Salivary cytokine profile in patients with oral lichen planus |
title_fullStr | Salivary cytokine profile in patients with oral lichen planus |
title_full_unstemmed | Salivary cytokine profile in patients with oral lichen planus |
title_short | Salivary cytokine profile in patients with oral lichen planus |
title_sort | salivary cytokine profile in patients with oral lichen planus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739733/ https://www.ncbi.nlm.nih.gov/pubmed/35028026 http://dx.doi.org/10.1016/j.jds.2021.06.013 |
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