Cargando…

Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial

IMPORTANCE: Intense interest exists in novel ω-3 formulations with high bioavailability to reduce blood triglyceride (TG) levels. OBJECTIVE: To determine the phase 3 efficacy and safety of a naturally derived krill oil with eicosapentaenoic acid and docosahexaenoic acid as both phospholipid esters (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mozaffarian, Dariush, Maki, Kevin C., Bays, Harold E., Aguilera, Fernando, Gould, Glenn, Hegele, Robert A., Moriarty, Patrick M., Robinson, Jennifer G., Shi, Peilin, Tur, Josefina F., Lapointe, Jean-François, Aziz, Sarya, Lemieux, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2022
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739762/ https://www.ncbi.nlm.nih.gov/pubmed/34989797 http://dx.doi.org/10.1001/jamanetworkopen.2021.41898

Ejemplares similares

Prescription ω−3 Therapy to Reduce Triglyceride Levels—A New Horizon for Cost-effective Therapy
por: Mozaffarian, Dariush
Publicado: (2022)

Hypertriglyceridemia
por: Brahm, Amanda, et al.
Publicado: (2013)

Genetics of Hypertriglyceridemia
por: Dron, Jacqueline S., et al.
Publicado: (2020)

Genetic determinants of pancreatitis: relevance in severe hypertriglyceridemia
por: Hang, Shyann M.T., et al.
Publicado: (2023)

SUN-593 Variants in Known Monogenic Causal Genes of Hypertriglyceridemia Are Not Major Contributors for Hypertriglyceridemia in Lipodystrophy Due to a LMNA Mutation
por: Ueda, Masako, et al.
Publicado: (2020)

A reexamination of krill oil bioavailability studies
por: Salem, Norman, et al.
Publicado: (2014)

PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE)
por: Murphy, Rachel A, et al.
Publicado: (2021)

Supplementation of krill oil with high phospholipid content increases sum of EPA and DHA in erythrocytes compared with low phospholipid krill oil
por: Ramprasath, V. R., et al.
Publicado: (2015)

A Head‐to‐Head Comparison of a Free Fatty Acid Formulation of Omega‐3 Pentaenoic Acids Versus Icosapent Ethyl in Adults With Hypertriglyceridemia: The ENHANCE‐IT Study
por: Maki, Kevin C., et al.
Publicado: (2022)

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects
por: Banni, Sebastiano, et al.
Publicado: (2011)

Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles
por: O’Dea, Louis St L, et al.
Publicado: (2019)

Preparation and Characterization of Microemulsions Based on Antarctic Krill Oil
por: Zhao, Jiawen, et al.
Publicado: (2020)

Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia
por: Cao, Henian, et al.
Publicado: (2008)

Bioavailability of fatty acids from krill oil, krill meal and fish oil in healthy subjects–a randomized, single-dose, cross-over trial
por: Köhler, Anton, et al.
Publicado: (2015)

Differential Effects of Krill Oil and Fish Oil on the Hepatic Transcriptome in Mice
por: Burri, Lena, et al.
Publicado: (2011)

Commentary on a trial comparing krill oil versus fish oil
por: Nichols, Peter D, et al.
Publicado: (2014)

Comparison of bioavailability of krill oil versus fish oil and health effect
por: Ulven, Stine M, et al.
Publicado: (2015)

Absorption rate of krill oil and fish oil in blood and brain of rats
por: Ahn, So Hyun, et al.
Publicado: (2018)

KrillDB: A de novo transcriptome database for the Antarctic krill (Euphausia superba)
por: Sales, Gabriele, et al.
Publicado: (2017)

Ocean-bottom krill sex
por: Kawaguchi, So, et al.
Publicado: (2011)

Identifying Risk: Concurrent Overlap of the Antarctic Krill Fishery with Krill-Dependent Predators in the Scotia Sea
por: Hinke, Jefferson T., et al.
Publicado: (2017)

Response to commentary on a trial comparing krill oil versus fish oil
por: Ramprasath, Vanu R, et al.
Publicado: (2014)

The FGF21 analog pegozafermin in severe hypertriglyceridemia: a randomized phase 2 trial
por: Bhatt, Deepak L., et al.
Publicado: (2023)

Assessing dietary intakes from household budget surveys: A national analysis in Bangladesh
por: Karageorgou, Dimitra, et al.
Publicado: (2018)

Supplementation of diet with krill oil protects against experimental rheumatoid arthritis
por: Ierna, Michelle, et al.
Publicado: (2010)

Elucidation of Phosphatidylcholine Composition in Krill Oil Extracted from Euphausia superba
por: Winther, Bjørn, et al.
Publicado: (2010)

The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function
por: Da Boit, Mariasole, et al.
Publicado: (2015)

Genotoxicity test and subchronic toxicity study with Superba™ krill oil in rats
por: Robertson, Bruce, et al.
Publicado: (2014)

Detection and Quantification of Adulteration in Krill Oil with Raman and Infrared Spectroscopic Methods
por: Ahmmed, Fatema, et al.
Publicado: (2023)

Krill Products: An Overview of Animal Studies
por: Burri, Lena, et al.
Publicado: (2015)

The importance of Antarctic krill in biogeochemical cycles
por: Cavan, E. L., et al.
Publicado: (2019)

Krill vs salps: dominance shift from krill to salps is associated with higher dissolved N:P ratios
por: Plum, Christoph, et al.
Publicado: (2020)

Hypertriglyceridemia and atherosclerosis
por: Peng, Jia, et al.
Publicado: (2017)

A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
por: Hegele, Robert A., et al.
Publicado: (2009)

Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
por: Fosshaug, Linn E, et al.
Publicado: (2011)

Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet
por: Ferramosca, Alessandra, et al.
Publicado: (2015)

Modulation of miRNA expression in aged rat hippocampus by buttermilk and krill oil
por: Crespo, M. Carmen, et al.
Publicado: (2018)

The comparison of krill oil extracted through ethanol–hexane method and subcritical method
por: Sun, Weiwei, et al.
Publicado: (2019)

Preparation of Antarctic Krill Oil Emulsion and Its Stability under Catalase Treatment
por: Zheng, Zhenxiao, et al.
Publicado: (2021)

Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats
por: Kim, Ok-Kyung, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uu4h48vjl8sn9ma0fnfp26m7il