Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H(3) and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

[Image: see text] In an attempt to extend recent studies showing that some clinically evaluated histamine H(3) receptor (H(3)R) antagonists possess nanomolar affinity at sigma-1 receptors (σ(1)R), we selected 20 representative structures among our previously reported H(3)R ligands to investigate the...

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Detalles Bibliográficos
Autores principales: Szczepańska, Katarzyna, Podlewska, Sabina, Dichiara, Maria, Gentile, Davide, Patamia, Vincenzo, Rosier, Niklas, Mönnich, Denise, Ruiz Cantero, Ma Carmen, Karcz, Tadeusz, Łażewska, Dorota, Siwek, Agata, Pockes, Steffen, Cobos, Enrique J., Marrazzo, Agostino, Stark, Holger, Rescifina, Antonio, Bojarski, Andrzej J., Amata, Emanuele, Kieć-Kononowicz, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739840/
https://www.ncbi.nlm.nih.gov/pubmed/34908391
http://dx.doi.org/10.1021/acschemneuro.1c00435

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