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Targeted Genetic Reduction of Mutant Huntingtin Lessens Cardiac Pathology in the BACHD Mouse Model of Huntington's Disease

Individuals affected by Huntington's disease (HD) present with progressive degeneration that results in a wide range of symptoms, including cardiovascular (CV) dysfunction. The huntingtin gene (HTT) and its product are ubiquitously expressed, hence, the cardiomyopathy could also be driven by de...

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Detalles Bibliográficos
Autores principales:	Park, Saemi, Luk, Shu Hon Christopher, Bains, Raj S., Whittaker, Daniel S., Chiem, Emily, Jordan, Maria C., Roos, Kenneth P., Ghiani, Cristina A., Colwell, Christopher S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739867/ https://www.ncbi.nlm.nih.gov/pubmed/35004919 http://dx.doi.org/10.3389/fcvm.2021.810810

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