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Legionnaires’ disease presenting with exanthem; Case and review of previously published cases
Infection with Legionella spp. (legionellosis) causes two distinct clinical presentations: Legionnaires’ Disease and Pontiac Fever. Legionnaire’s Disease primarily involves the lungs, often with accompanying gastrointestinal symptoms, and can also affect the liver, central nervous system, and kidney...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739871/ https://www.ncbi.nlm.nih.gov/pubmed/35028294 http://dx.doi.org/10.1016/j.idcr.2022.e01376 |
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author | Carter, Christine J. Corley, Elizabeth M. Canepa, Hannah Schmalzle, Sarah A. |
author_facet | Carter, Christine J. Corley, Elizabeth M. Canepa, Hannah Schmalzle, Sarah A. |
author_sort | Carter, Christine J. |
collection | PubMed |
description | Infection with Legionella spp. (legionellosis) causes two distinct clinical presentations: Legionnaires’ Disease and Pontiac Fever. Legionnaire’s Disease primarily involves the lungs, often with accompanying gastrointestinal symptoms, and can also affect the liver, central nervous system, and kidneys, and cause metabolic derangements. Manifestations in the integumentary system are rare; to date, there have been eleven cases reported in the literature of Legionellosis with associated rash, with varied presentation. The relationship between Legionella pneumophila and the skin has not yet been clearly defined; immunological and/or toxic pathogenesis are possible. We report a case of Legionnaires’ Disease in a young immunocompromised man with a largely benign clinical course consisting of predominantly gastrointestinal symptoms and an extensive maculopapular rash. Chest radiography showed lobar infiltrate in the absence of clinical symptoms of pneumonia. The importance of this case is for clinicians to maintain high clinical suspicion for Legionella when extra-pulmonary symptoms predominate, specifically in immunocompromised hosts who may have atypical presentations and have higher mortality rates when treatment is delayed. |
format | Online Article Text |
id | pubmed-8739871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-87398712022-01-12 Legionnaires’ disease presenting with exanthem; Case and review of previously published cases Carter, Christine J. Corley, Elizabeth M. Canepa, Hannah Schmalzle, Sarah A. IDCases Case Report Infection with Legionella spp. (legionellosis) causes two distinct clinical presentations: Legionnaires’ Disease and Pontiac Fever. Legionnaire’s Disease primarily involves the lungs, often with accompanying gastrointestinal symptoms, and can also affect the liver, central nervous system, and kidneys, and cause metabolic derangements. Manifestations in the integumentary system are rare; to date, there have been eleven cases reported in the literature of Legionellosis with associated rash, with varied presentation. The relationship between Legionella pneumophila and the skin has not yet been clearly defined; immunological and/or toxic pathogenesis are possible. We report a case of Legionnaires’ Disease in a young immunocompromised man with a largely benign clinical course consisting of predominantly gastrointestinal symptoms and an extensive maculopapular rash. Chest radiography showed lobar infiltrate in the absence of clinical symptoms of pneumonia. The importance of this case is for clinicians to maintain high clinical suspicion for Legionella when extra-pulmonary symptoms predominate, specifically in immunocompromised hosts who may have atypical presentations and have higher mortality rates when treatment is delayed. Elsevier 2022-01-03 /pmc/articles/PMC8739871/ /pubmed/35028294 http://dx.doi.org/10.1016/j.idcr.2022.e01376 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Carter, Christine J. Corley, Elizabeth M. Canepa, Hannah Schmalzle, Sarah A. Legionnaires’ disease presenting with exanthem; Case and review of previously published cases |
title | Legionnaires’ disease presenting with exanthem; Case and review of previously published cases |
title_full | Legionnaires’ disease presenting with exanthem; Case and review of previously published cases |
title_fullStr | Legionnaires’ disease presenting with exanthem; Case and review of previously published cases |
title_full_unstemmed | Legionnaires’ disease presenting with exanthem; Case and review of previously published cases |
title_short | Legionnaires’ disease presenting with exanthem; Case and review of previously published cases |
title_sort | legionnaires’ disease presenting with exanthem; case and review of previously published cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739871/ https://www.ncbi.nlm.nih.gov/pubmed/35028294 http://dx.doi.org/10.1016/j.idcr.2022.e01376 |
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