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Outcomes Associated With Osteochondral Allograft Transplantation in Dogs

The purpose of this study was to retrospectively characterize outcomes and complications associated with osteochondral allograft transplantation for treating chondral and osteochondral lesions in a group of client-owned dogs with naturally-occurring disease. Records were reviewed for information on...

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Autores principales: Franklin, Samuel P., Stoker, Aaron M., Murphy, Sean M., Kowaleski, Michael P., Gillick, Mitchell, Kim, Stanley E., Karlin, Michael, Cross, Alan, Cook, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739896/
https://www.ncbi.nlm.nih.gov/pubmed/35004920
http://dx.doi.org/10.3389/fvets.2021.759610
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author Franklin, Samuel P.
Stoker, Aaron M.
Murphy, Sean M.
Kowaleski, Michael P.
Gillick, Mitchell
Kim, Stanley E.
Karlin, Michael
Cross, Alan
Cook, James L.
author_facet Franklin, Samuel P.
Stoker, Aaron M.
Murphy, Sean M.
Kowaleski, Michael P.
Gillick, Mitchell
Kim, Stanley E.
Karlin, Michael
Cross, Alan
Cook, James L.
author_sort Franklin, Samuel P.
collection PubMed
description The purpose of this study was to retrospectively characterize outcomes and complications associated with osteochondral allograft transplantation for treating chondral and osteochondral lesions in a group of client-owned dogs with naturally-occurring disease. Records were reviewed for information on signalment, treated joint, underlying pathology (e.g., osteochondritis dissecans; OCD), and type, size, and number of grafts used. Complications were classified as “trivial” if no treatment was provided, “non-surgical” if non-surgical treatment were needed, “minor surgical” if a minor surgical procedure such as pin removal were needed but the graft survived and function was acceptable, or “major” if the graft failed and revision surgery were needed. Outcomes were classified as unacceptable, acceptable, or full function. Thirty-five joints in 33 dogs were treated including nine stifles with lateral femoral condyle (LFC) OCD and 10 stifles with medial femoral condyle (MFC) OCD treated with osteochondral cylinders or “plugs.” There were 16 “complex” procedures of the shoulder, elbow, hip, stifle, and tarsus using custom-cut grafts. In total there were eight trivial complications, one non-surgical complication, two minor surgical complications, and five major complications for a total of 16/35 cases with complications. Accordingly, there were five cases with unacceptable outcomes, all of whom had major complications while the other 30 cases had successful outcomes. Of the 30 cases with successful outcomes, 15 had full function and 15 had acceptable function. Based on these subjective outcome assessments, it appears osteochondral allograft transplantation is a viable treatment option in dogs with focal or complex cartilage defects. However, no conclusions can be made regarding the inferiority or superiority of allograft transplantation in comparison to other treatment options based upon these data.
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spelling pubmed-87398962022-01-08 Outcomes Associated With Osteochondral Allograft Transplantation in Dogs Franklin, Samuel P. Stoker, Aaron M. Murphy, Sean M. Kowaleski, Michael P. Gillick, Mitchell Kim, Stanley E. Karlin, Michael Cross, Alan Cook, James L. Front Vet Sci Veterinary Science The purpose of this study was to retrospectively characterize outcomes and complications associated with osteochondral allograft transplantation for treating chondral and osteochondral lesions in a group of client-owned dogs with naturally-occurring disease. Records were reviewed for information on signalment, treated joint, underlying pathology (e.g., osteochondritis dissecans; OCD), and type, size, and number of grafts used. Complications were classified as “trivial” if no treatment was provided, “non-surgical” if non-surgical treatment were needed, “minor surgical” if a minor surgical procedure such as pin removal were needed but the graft survived and function was acceptable, or “major” if the graft failed and revision surgery were needed. Outcomes were classified as unacceptable, acceptable, or full function. Thirty-five joints in 33 dogs were treated including nine stifles with lateral femoral condyle (LFC) OCD and 10 stifles with medial femoral condyle (MFC) OCD treated with osteochondral cylinders or “plugs.” There were 16 “complex” procedures of the shoulder, elbow, hip, stifle, and tarsus using custom-cut grafts. In total there were eight trivial complications, one non-surgical complication, two minor surgical complications, and five major complications for a total of 16/35 cases with complications. Accordingly, there were five cases with unacceptable outcomes, all of whom had major complications while the other 30 cases had successful outcomes. Of the 30 cases with successful outcomes, 15 had full function and 15 had acceptable function. Based on these subjective outcome assessments, it appears osteochondral allograft transplantation is a viable treatment option in dogs with focal or complex cartilage defects. However, no conclusions can be made regarding the inferiority or superiority of allograft transplantation in comparison to other treatment options based upon these data. Frontiers Media S.A. 2021-12-24 /pmc/articles/PMC8739896/ /pubmed/35004920 http://dx.doi.org/10.3389/fvets.2021.759610 Text en Copyright © 2021 Franklin, Stoker, Murphy, Kowaleski, Gillick, Kim, Karlin, Cross and Cook. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Franklin, Samuel P.
Stoker, Aaron M.
Murphy, Sean M.
Kowaleski, Michael P.
Gillick, Mitchell
Kim, Stanley E.
Karlin, Michael
Cross, Alan
Cook, James L.
Outcomes Associated With Osteochondral Allograft Transplantation in Dogs
title Outcomes Associated With Osteochondral Allograft Transplantation in Dogs
title_full Outcomes Associated With Osteochondral Allograft Transplantation in Dogs
title_fullStr Outcomes Associated With Osteochondral Allograft Transplantation in Dogs
title_full_unstemmed Outcomes Associated With Osteochondral Allograft Transplantation in Dogs
title_short Outcomes Associated With Osteochondral Allograft Transplantation in Dogs
title_sort outcomes associated with osteochondral allograft transplantation in dogs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739896/
https://www.ncbi.nlm.nih.gov/pubmed/35004920
http://dx.doi.org/10.3389/fvets.2021.759610
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