Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back

Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characterist...

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Detalles Bibliográficos
Autores principales: Chiba, Hiromu, Kambayashi, Yumi, Tamabuchi, Erika, Hashimoto, Akira, Fujimura, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739937/
https://www.ncbi.nlm.nih.gov/pubmed/35082639
http://dx.doi.org/10.1159/000520971
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author Chiba, Hiromu
Kambayashi, Yumi
Tamabuchi, Erika
Hashimoto, Akira
Fujimura, Taku
author_facet Chiba, Hiromu
Kambayashi, Yumi
Tamabuchi, Erika
Hashimoto, Akira
Fujimura, Taku
author_sort Chiba, Hiromu
collection PubMed
description Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.
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spelling pubmed-87399372022-01-25 Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back Chiba, Hiromu Kambayashi, Yumi Tamabuchi, Erika Hashimoto, Akira Fujimura, Taku Case Rep Oncol Case Report Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future. S. Karger AG 2021-12-13 /pmc/articles/PMC8739937/ /pubmed/35082639 http://dx.doi.org/10.1159/000520971 Text en Copyright © 2021 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Chiba, Hiromu
Kambayashi, Yumi
Tamabuchi, Erika
Hashimoto, Akira
Fujimura, Taku
Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
title Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
title_full Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
title_fullStr Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
title_full_unstemmed Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
title_short Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
title_sort matrix metalloproteinase 28-bearing microcystic adnexal carcinoma on the back
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739937/
https://www.ncbi.nlm.nih.gov/pubmed/35082639
http://dx.doi.org/10.1159/000520971
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