A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion

MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a nu...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Samadian, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740132/
https://www.ncbi.nlm.nih.gov/pubmed/35004844
http://dx.doi.org/10.3389/fmolb.2021.763338
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Samadian, Mohammad
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Samadian, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of in vitro, animal and human investigations about the impact of miR-1290 in the development of malignancies.
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spelling pubmed-87401322022-01-08 A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Samadian, Mohammad Front Mol Biosci Molecular Biosciences MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of in vitro, animal and human investigations about the impact of miR-1290 in the development of malignancies. Frontiers Media S.A. 2021-12-24 /pmc/articles/PMC8740132/ /pubmed/35004844 http://dx.doi.org/10.3389/fmolb.2021.763338 Text en Copyright © 2021 Ghafouri-Fard, Khoshbakht, Hussen, Taheri and Samadian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Samadian, Mohammad
A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion
title A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion
title_full A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion
title_fullStr A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion
title_full_unstemmed A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion
title_short A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion
title_sort review on the role of mir-1290 in cell proliferation, apoptosis and invasion
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740132/
https://www.ncbi.nlm.nih.gov/pubmed/35004844
http://dx.doi.org/10.3389/fmolb.2021.763338
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