Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficul...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiso, Sayaka, Sugiura, Hiroyuki, Kuroi, Taiga, Omote, Rika, Toji, Tomohiro, Ishikawa, Tatsunori, Okamoto, Sachiyo, Nomura, Naho, Masunari, Taro, Sezaki, Nobuo, Kiguchi, Toru, Tanimoto, Mitsune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740142/
https://www.ncbi.nlm.nih.gov/pubmed/35082632
http://dx.doi.org/10.1159/000520427
Descripción
Sumario:The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient's lifetime because of the atypical phenotype. However, autopsy revealed that the patient's bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.

Ejemplares similares