Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions()

Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-med...

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Detalles Bibliográficos
Autores principales: Potęga, Agnieszka, Kosno, Michał, Mazerska, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740389/
https://www.ncbi.nlm.nih.gov/pubmed/35028185
http://dx.doi.org/10.1016/j.jpha.2021.03.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740389/
https://www.ncbi.nlm.nih.gov/pubmed/35028185
http://dx.doi.org/10.1016/j.jpha.2021.03.014

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