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Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study
BACKGROUND: We evaluated the risk of developing primary open-angle glaucoma (POAG) according to androgen deprivation therapy (ADT) status in patients with prostate cancer. MATERIALS AND METHODS: From the nationwide claims database in South Korea, 218,203 men with prostate cancer were identified betw...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Pacific Prostate Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740392/ https://www.ncbi.nlm.nih.gov/pubmed/35059357 http://dx.doi.org/10.1016/j.prnil.2021.05.001 |
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author | Ahn, Hyun Kyu Lee, Hye Sun Park, Ju-Young Kim, Do Kyung Kim, Min Hwang, Ho Sik Kim, Jong Won Ha, Jee Soo Cho, Kang Su |
author_facet | Ahn, Hyun Kyu Lee, Hye Sun Park, Ju-Young Kim, Do Kyung Kim, Min Hwang, Ho Sik Kim, Jong Won Ha, Jee Soo Cho, Kang Su |
author_sort | Ahn, Hyun Kyu |
collection | PubMed |
description | BACKGROUND: We evaluated the risk of developing primary open-angle glaucoma (POAG) according to androgen deprivation therapy (ADT) status in patients with prostate cancer. MATERIALS AND METHODS: From the nationwide claims database in South Korea, 218,203 men with prostate cancer were identified between 2008 and 2017. After applying the inclusion and exclusion criteria, a total of 170,701 patients (42,877 in the ADT and non-ADT groups and 127,824 in the non-ADT group) were included in the analysis. To adjust for comorbidities between cohorts, exact matching was performed. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of POAG associated with ADT after controlling for potential confounding factors. RESULTS: In the matched cohort, the ADT group had a lower proportion of newly developed POAG than the non-ADT group (2.10% vs. 2.88%, respectively; P < 0.0001). Multivariable analysis revealed that the ADT group had a significantly lower risk of POAG than the non-ADT group (HR, 0.808; 95% CI, 0.739–0.884; P < 0.0001). The risk of POAG was lower in patients who underwent ADT for less than 2 years (HR, 0.782; 95% CI, 0.690–0.886; P = 0.0001) and in those receiving ADT for over 2 years (HR, 0.825; 95% CI, 0.744–0.916; P = 0.0003) compared with the non-ADT group. CONCLUSIONS: The use of ADT was associated with a decreased risk of POAG in Korean patients with prostate cancer. Our findings suggest that testosterone may be involved in the pathophysiology of POAG, and this should be confirmed through further studies. |
format | Online Article Text |
id | pubmed-8740392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Asian Pacific Prostate Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87403922022-01-19 Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study Ahn, Hyun Kyu Lee, Hye Sun Park, Ju-Young Kim, Do Kyung Kim, Min Hwang, Ho Sik Kim, Jong Won Ha, Jee Soo Cho, Kang Su Prostate Int Research Article BACKGROUND: We evaluated the risk of developing primary open-angle glaucoma (POAG) according to androgen deprivation therapy (ADT) status in patients with prostate cancer. MATERIALS AND METHODS: From the nationwide claims database in South Korea, 218,203 men with prostate cancer were identified between 2008 and 2017. After applying the inclusion and exclusion criteria, a total of 170,701 patients (42,877 in the ADT and non-ADT groups and 127,824 in the non-ADT group) were included in the analysis. To adjust for comorbidities between cohorts, exact matching was performed. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of POAG associated with ADT after controlling for potential confounding factors. RESULTS: In the matched cohort, the ADT group had a lower proportion of newly developed POAG than the non-ADT group (2.10% vs. 2.88%, respectively; P < 0.0001). Multivariable analysis revealed that the ADT group had a significantly lower risk of POAG than the non-ADT group (HR, 0.808; 95% CI, 0.739–0.884; P < 0.0001). The risk of POAG was lower in patients who underwent ADT for less than 2 years (HR, 0.782; 95% CI, 0.690–0.886; P = 0.0001) and in those receiving ADT for over 2 years (HR, 0.825; 95% CI, 0.744–0.916; P = 0.0003) compared with the non-ADT group. CONCLUSIONS: The use of ADT was associated with a decreased risk of POAG in Korean patients with prostate cancer. Our findings suggest that testosterone may be involved in the pathophysiology of POAG, and this should be confirmed through further studies. Asian Pacific Prostate Society 2021-12 2021-05-29 /pmc/articles/PMC8740392/ /pubmed/35059357 http://dx.doi.org/10.1016/j.prnil.2021.05.001 Text en © 2021 Asian Pacific Prostate Society. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Ahn, Hyun Kyu Lee, Hye Sun Park, Ju-Young Kim, Do Kyung Kim, Min Hwang, Ho Sik Kim, Jong Won Ha, Jee Soo Cho, Kang Su Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
title | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
title_full | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
title_fullStr | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
title_full_unstemmed | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
title_short | Androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
title_sort | androgen deprivation therapy may reduce the risk of primary open-angle glaucoma in patients with prostate cancer: a nationwide population-based cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740392/ https://www.ncbi.nlm.nih.gov/pubmed/35059357 http://dx.doi.org/10.1016/j.prnil.2021.05.001 |
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