Progress on the roles of MEF2C in neuropsychiatric diseases

Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsy...

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Autores principales: Zhang, Zhikun, Zhao, Yongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740500/
https://www.ncbi.nlm.nih.gov/pubmed/34991657
http://dx.doi.org/10.1186/s13041-021-00892-6
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author Zhang, Zhikun
Zhao, Yongxiang
author_facet Zhang, Zhikun
Zhao, Yongxiang
author_sort Zhang, Zhikun
collection PubMed
description Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer’s disease (AD). Here, we review the relationship between MEF2C and neuropsychiatric disorders, and provide further insights into the mechanism of these diseases.
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spelling pubmed-87405002022-01-07 Progress on the roles of MEF2C in neuropsychiatric diseases Zhang, Zhikun Zhao, Yongxiang Mol Brain Review Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer’s disease (AD). Here, we review the relationship between MEF2C and neuropsychiatric disorders, and provide further insights into the mechanism of these diseases. BioMed Central 2022-01-06 /pmc/articles/PMC8740500/ /pubmed/34991657 http://dx.doi.org/10.1186/s13041-021-00892-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Zhikun
Zhao, Yongxiang
Progress on the roles of MEF2C in neuropsychiatric diseases
title Progress on the roles of MEF2C in neuropsychiatric diseases
title_full Progress on the roles of MEF2C in neuropsychiatric diseases
title_fullStr Progress on the roles of MEF2C in neuropsychiatric diseases
title_full_unstemmed Progress on the roles of MEF2C in neuropsychiatric diseases
title_short Progress on the roles of MEF2C in neuropsychiatric diseases
title_sort progress on the roles of mef2c in neuropsychiatric diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740500/
https://www.ncbi.nlm.nih.gov/pubmed/34991657
http://dx.doi.org/10.1186/s13041-021-00892-6
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