Cargando…
Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats
Polybrominated diphenyl ethers (PBDEs) are legacy compounds with continued widespread human exposure. Despite this, developmental toxicity studies of DE-71, a mixture of PBDEs, are scarce and its potential for endocrine disrupting effects in vivo is not well covered. To address this knowledge gap, w...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740517/ https://www.ncbi.nlm.nih.gov/pubmed/35036103 http://dx.doi.org/10.7717/peerj.12738 |
_version_ | 1784629331326140416 |
---|---|
author | Ramhøj, Louise Mandrup, Karen Hass, Ulla Svingen, Terje Axelstad, Marta |
author_facet | Ramhøj, Louise Mandrup, Karen Hass, Ulla Svingen, Terje Axelstad, Marta |
author_sort | Ramhøj, Louise |
collection | PubMed |
description | Polybrominated diphenyl ethers (PBDEs) are legacy compounds with continued widespread human exposure. Despite this, developmental toxicity studies of DE-71, a mixture of PBDEs, are scarce and its potential for endocrine disrupting effects in vivo is not well covered. To address this knowledge gap, we carried out a developmental exposure study with DE-71. Pregnant Wistar rat dams were exposed to 0, 40 or 60 mg/kg bodyweight/day from gestation day 7 to postnatal day 16, and both sexes were examined. Developmental exposure affected a range of reproductive toxicity endpoints. Effects were seen for both male and female anogenital distances (AGD), with exposed offspring of either sex displaying around 10% shorter AGD compared to controls. Both absolute and relative prostate weights were markedly reduced in exposed male offspring, with about 40% relative to controls. DE-71 reduced mammary gland outgrowth, especially in male offspring. These developmental in vivo effects suggest a complex effect pattern involving anti-androgenic, anti-estrogenic and maybe estrogenic mechanisms depending on tissues and developmental stages. Irrespective of the specific underlying mechanisms, these in vivo results corroborate that DE-71 causes endocrine disrupting effects and raises concern for the effects of PBDE-exposure on human reproductive health, including any potential long-term consequences of disrupted mammary gland development. |
format | Online Article Text |
id | pubmed-8740517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87405172022-01-14 Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats Ramhøj, Louise Mandrup, Karen Hass, Ulla Svingen, Terje Axelstad, Marta PeerJ Developmental Biology Polybrominated diphenyl ethers (PBDEs) are legacy compounds with continued widespread human exposure. Despite this, developmental toxicity studies of DE-71, a mixture of PBDEs, are scarce and its potential for endocrine disrupting effects in vivo is not well covered. To address this knowledge gap, we carried out a developmental exposure study with DE-71. Pregnant Wistar rat dams were exposed to 0, 40 or 60 mg/kg bodyweight/day from gestation day 7 to postnatal day 16, and both sexes were examined. Developmental exposure affected a range of reproductive toxicity endpoints. Effects were seen for both male and female anogenital distances (AGD), with exposed offspring of either sex displaying around 10% shorter AGD compared to controls. Both absolute and relative prostate weights were markedly reduced in exposed male offspring, with about 40% relative to controls. DE-71 reduced mammary gland outgrowth, especially in male offspring. These developmental in vivo effects suggest a complex effect pattern involving anti-androgenic, anti-estrogenic and maybe estrogenic mechanisms depending on tissues and developmental stages. Irrespective of the specific underlying mechanisms, these in vivo results corroborate that DE-71 causes endocrine disrupting effects and raises concern for the effects of PBDE-exposure on human reproductive health, including any potential long-term consequences of disrupted mammary gland development. PeerJ Inc. 2022-01-04 /pmc/articles/PMC8740517/ /pubmed/35036103 http://dx.doi.org/10.7717/peerj.12738 Text en ©2022 Ramhøj et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Developmental Biology Ramhøj, Louise Mandrup, Karen Hass, Ulla Svingen, Terje Axelstad, Marta Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
title | Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
title_full | Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
title_fullStr | Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
title_full_unstemmed | Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
title_short | Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
title_sort | developmental exposure to the de-71 mixture of polybrominated diphenyl ether (pbde) flame retardants induce a complex pattern of endocrine disrupting effects in rats |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740517/ https://www.ncbi.nlm.nih.gov/pubmed/35036103 http://dx.doi.org/10.7717/peerj.12738 |
work_keys_str_mv | AT ramhøjlouise developmentalexposuretothede71mixtureofpolybrominateddiphenyletherpbdeflameretardantsinduceacomplexpatternofendocrinedisruptingeffectsinrats AT mandrupkaren developmentalexposuretothede71mixtureofpolybrominateddiphenyletherpbdeflameretardantsinduceacomplexpatternofendocrinedisruptingeffectsinrats AT hassulla developmentalexposuretothede71mixtureofpolybrominateddiphenyletherpbdeflameretardantsinduceacomplexpatternofendocrinedisruptingeffectsinrats AT svingenterje developmentalexposuretothede71mixtureofpolybrominateddiphenyletherpbdeflameretardantsinduceacomplexpatternofendocrinedisruptingeffectsinrats AT axelstadmarta developmentalexposuretothede71mixtureofpolybrominateddiphenyletherpbdeflameretardantsinduceacomplexpatternofendocrinedisruptingeffectsinrats |