Cargando…
Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
PURPOSE: The purpose of this study was to investigate the correlations between peripapillary choroidal thickness (PCT) and nonarteritic ischemic optic neuropathy (NAION) by using semiautomated optic coherence tomography (OCT). METHODS: A total of 35 NAION eyes, 29 unaffected fellow eyes, and 40 eyes...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740530/ https://www.ncbi.nlm.nih.gov/pubmed/34964834 http://dx.doi.org/10.1167/tvst.10.14.31 |
_version_ | 1784629333135982592 |
---|---|
author | Hou, Yi-Ting Chen, Ta-Ching Yeh, Chao-Yuan Lin, Chao-Wen |
author_facet | Hou, Yi-Ting Chen, Ta-Ching Yeh, Chao-Yuan Lin, Chao-Wen |
author_sort | Hou, Yi-Ting |
collection | PubMed |
description | PURPOSE: The purpose of this study was to investigate the correlations between peripapillary choroidal thickness (PCT) and nonarteritic ischemic optic neuropathy (NAION) by using semiautomated optic coherence tomography (OCT). METHODS: A total of 35 NAION eyes, 29 unaffected fellow eyes, and 40 eyes from an age-matched control group were recruited. Enhanced-depth imaging OCT was performed after the resolution of disc edema. PCT was measured using a customized semiautomated MATLAB program. Regression models adjusted for multiple variables were used to inspect the correlation between mean PCT and NAION. RESULTS: The mean PCT in NAION eyes, unaffected fellow eyes, and the control group was 197.09 ± 38.09, 196.52 ± 38.47, and 153.53 ± 29.92 µm, respectively. The mean PCT was significantly thicker both in NAION-affected eyes and fellow eyes compared with the control group (P < 0.001). No significant difference existed between NAION-affected eyes and unaffected fellow eyes. The PCT of the superior quadrant was significantly thicker than that of the inferior quadrant in all three groups. In the multivariate logistic regression, PCT was the only predisposing factor for NAION. However, the value of the PCT was not correlated with final visual outcomes. CONCLUSIONS: With a semiautomated program to alleviate the missing measurements, our study demonstrated significantly thicker PCT in both NAION-affected and unaffected eyes of patients, which indicated that peripapillary pachychoroid is a predisposing factor for NAION but may not be a prognostic factor for visual outcomes. TRANSLATIONAL RELEVANCE: Accurate measurement of PCT by using semiautomated OCT illustrates the correlation between choroidal vasculature and NAION. |
format | Online Article Text |
id | pubmed-8740530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-87405302022-01-14 Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study Hou, Yi-Ting Chen, Ta-Ching Yeh, Chao-Yuan Lin, Chao-Wen Transl Vis Sci Technol Article PURPOSE: The purpose of this study was to investigate the correlations between peripapillary choroidal thickness (PCT) and nonarteritic ischemic optic neuropathy (NAION) by using semiautomated optic coherence tomography (OCT). METHODS: A total of 35 NAION eyes, 29 unaffected fellow eyes, and 40 eyes from an age-matched control group were recruited. Enhanced-depth imaging OCT was performed after the resolution of disc edema. PCT was measured using a customized semiautomated MATLAB program. Regression models adjusted for multiple variables were used to inspect the correlation between mean PCT and NAION. RESULTS: The mean PCT in NAION eyes, unaffected fellow eyes, and the control group was 197.09 ± 38.09, 196.52 ± 38.47, and 153.53 ± 29.92 µm, respectively. The mean PCT was significantly thicker both in NAION-affected eyes and fellow eyes compared with the control group (P < 0.001). No significant difference existed between NAION-affected eyes and unaffected fellow eyes. The PCT of the superior quadrant was significantly thicker than that of the inferior quadrant in all three groups. In the multivariate logistic regression, PCT was the only predisposing factor for NAION. However, the value of the PCT was not correlated with final visual outcomes. CONCLUSIONS: With a semiautomated program to alleviate the missing measurements, our study demonstrated significantly thicker PCT in both NAION-affected and unaffected eyes of patients, which indicated that peripapillary pachychoroid is a predisposing factor for NAION but may not be a prognostic factor for visual outcomes. TRANSLATIONAL RELEVANCE: Accurate measurement of PCT by using semiautomated OCT illustrates the correlation between choroidal vasculature and NAION. The Association for Research in Vision and Ophthalmology 2021-12-29 /pmc/articles/PMC8740530/ /pubmed/34964834 http://dx.doi.org/10.1167/tvst.10.14.31 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Article Hou, Yi-Ting Chen, Ta-Ching Yeh, Chao-Yuan Lin, Chao-Wen Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study |
title | Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study |
title_full | Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study |
title_fullStr | Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study |
title_full_unstemmed | Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study |
title_short | Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study |
title_sort | peripapillary choroid thickness as a predisposing factor for nonarteritic anterior ischemic optic neuropathy: a semiautomated oct study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740530/ https://www.ncbi.nlm.nih.gov/pubmed/34964834 http://dx.doi.org/10.1167/tvst.10.14.31 |
work_keys_str_mv | AT houyiting peripapillarychoroidthicknessasapredisposingfactorfornonarteriticanteriorischemicopticneuropathyasemiautomatedoctstudy AT chentaching peripapillarychoroidthicknessasapredisposingfactorfornonarteriticanteriorischemicopticneuropathyasemiautomatedoctstudy AT yehchaoyuan peripapillarychoroidthicknessasapredisposingfactorfornonarteriticanteriorischemicopticneuropathyasemiautomatedoctstudy AT linchaowen peripapillarychoroidthicknessasapredisposingfactorfornonarteriticanteriorischemicopticneuropathyasemiautomatedoctstudy |