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Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study

PURPOSE: The purpose of this study was to investigate the correlations between peripapillary choroidal thickness (PCT) and nonarteritic ischemic optic neuropathy (NAION) by using semiautomated optic coherence tomography (OCT). METHODS: A total of 35 NAION eyes, 29 unaffected fellow eyes, and 40 eyes...

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Autores principales: Hou, Yi-Ting, Chen, Ta-Ching, Yeh, Chao-Yuan, Lin, Chao-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740530/
https://www.ncbi.nlm.nih.gov/pubmed/34964834
http://dx.doi.org/10.1167/tvst.10.14.31
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author Hou, Yi-Ting
Chen, Ta-Ching
Yeh, Chao-Yuan
Lin, Chao-Wen
author_facet Hou, Yi-Ting
Chen, Ta-Ching
Yeh, Chao-Yuan
Lin, Chao-Wen
author_sort Hou, Yi-Ting
collection PubMed
description PURPOSE: The purpose of this study was to investigate the correlations between peripapillary choroidal thickness (PCT) and nonarteritic ischemic optic neuropathy (NAION) by using semiautomated optic coherence tomography (OCT). METHODS: A total of 35 NAION eyes, 29 unaffected fellow eyes, and 40 eyes from an age-matched control group were recruited. Enhanced-depth imaging OCT was performed after the resolution of disc edema. PCT was measured using a customized semiautomated MATLAB program. Regression models adjusted for multiple variables were used to inspect the correlation between mean PCT and NAION. RESULTS: The mean PCT in NAION eyes, unaffected fellow eyes, and the control group was 197.09 ± 38.09, 196.52 ± 38.47, and 153.53 ± 29.92 µm, respectively. The mean PCT was significantly thicker both in NAION-affected eyes and fellow eyes compared with the control group (P < 0.001). No significant difference existed between NAION-affected eyes and unaffected fellow eyes. The PCT of the superior quadrant was significantly thicker than that of the inferior quadrant in all three groups. In the multivariate logistic regression, PCT was the only predisposing factor for NAION. However, the value of the PCT was not correlated with final visual outcomes. CONCLUSIONS: With a semiautomated program to alleviate the missing measurements, our study demonstrated significantly thicker PCT in both NAION-affected and unaffected eyes of patients, which indicated that peripapillary pachychoroid is a predisposing factor for NAION but may not be a prognostic factor for visual outcomes. TRANSLATIONAL RELEVANCE: Accurate measurement of PCT by using semiautomated OCT illustrates the correlation between choroidal vasculature and NAION.
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spelling pubmed-87405302022-01-14 Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study Hou, Yi-Ting Chen, Ta-Ching Yeh, Chao-Yuan Lin, Chao-Wen Transl Vis Sci Technol Article PURPOSE: The purpose of this study was to investigate the correlations between peripapillary choroidal thickness (PCT) and nonarteritic ischemic optic neuropathy (NAION) by using semiautomated optic coherence tomography (OCT). METHODS: A total of 35 NAION eyes, 29 unaffected fellow eyes, and 40 eyes from an age-matched control group were recruited. Enhanced-depth imaging OCT was performed after the resolution of disc edema. PCT was measured using a customized semiautomated MATLAB program. Regression models adjusted for multiple variables were used to inspect the correlation between mean PCT and NAION. RESULTS: The mean PCT in NAION eyes, unaffected fellow eyes, and the control group was 197.09 ± 38.09, 196.52 ± 38.47, and 153.53 ± 29.92 µm, respectively. The mean PCT was significantly thicker both in NAION-affected eyes and fellow eyes compared with the control group (P < 0.001). No significant difference existed between NAION-affected eyes and unaffected fellow eyes. The PCT of the superior quadrant was significantly thicker than that of the inferior quadrant in all three groups. In the multivariate logistic regression, PCT was the only predisposing factor for NAION. However, the value of the PCT was not correlated with final visual outcomes. CONCLUSIONS: With a semiautomated program to alleviate the missing measurements, our study demonstrated significantly thicker PCT in both NAION-affected and unaffected eyes of patients, which indicated that peripapillary pachychoroid is a predisposing factor for NAION but may not be a prognostic factor for visual outcomes. TRANSLATIONAL RELEVANCE: Accurate measurement of PCT by using semiautomated OCT illustrates the correlation between choroidal vasculature and NAION. The Association for Research in Vision and Ophthalmology 2021-12-29 /pmc/articles/PMC8740530/ /pubmed/34964834 http://dx.doi.org/10.1167/tvst.10.14.31 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Article
Hou, Yi-Ting
Chen, Ta-Ching
Yeh, Chao-Yuan
Lin, Chao-Wen
Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
title Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
title_full Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
title_fullStr Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
title_full_unstemmed Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
title_short Peripapillary Choroid Thickness as a Predisposing Factor for Nonarteritic Anterior Ischemic Optic Neuropathy: A Semiautomated OCT Study
title_sort peripapillary choroid thickness as a predisposing factor for nonarteritic anterior ischemic optic neuropathy: a semiautomated oct study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740530/
https://www.ncbi.nlm.nih.gov/pubmed/34964834
http://dx.doi.org/10.1167/tvst.10.14.31
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