Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages

The interaction of signal regulatory protein α (SIRPα) on macrophages with CD47 on cancer cells is thought to prevent antibody (Ab)-dependent cellular phagocytosis (ADCP) of the latter cells by the former. Blockade of the CD47-SIRPα interaction by Abs to CD47 or to SIRPα, in combination with tumor-t...

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Detalles Bibliográficos
Autores principales: Sakamoto, Mariko, Murata, Yoji, Tanaka, Daisuke, Kakuchi, Yuka, Okamoto, Takeshi, Hazama, Daisuke, Saito, Yasuyuki, Kotani, Takenori, Ohnishi, Hiroshi, Miyasaka, Masayuki, Fujisawa, Masato, Matozaki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740680/
https://www.ncbi.nlm.nih.gov/pubmed/34949714
http://dx.doi.org/10.1073/pnas.2109923118

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