Comparative Evaluation of Changes in Physiological and Psychomotor Effects in Pediatric Patients during Extraction under Different Concentrations of Nitrous Oxide–Oxygen Inhalation Sedation

INTRODUCTION: Nonpharmacological behavioral management techniques are routinely used to create an environment that facilitates and builds a rapport between the child and the dentist to carry out procedures with minimal disruption. However, the discomfort associated with oral injections produces varying degrees of stress in all patients. Nitrous oxide (N(2)O)–oxygen (O(2)) inhalation sedation is one of the most widely used modalities for the management of fear and anxiety in children. OBJECTIVE: The objective was to evaluate changes in physiological and psychomotor effects in pediatric patients during extraction under different concentrations of N(2)O–O(2) inhalation sedation. MATERIALS AND METHODS: A total of 300 healthy patients in the age range of 6–12 years (mean 8.9 years), who needed extraction of primary tooth, were included in the study. Pulse rate, SpO(2,) blood pressure (BP), and temperature were recorded at baseline, 30% N(2)O concentration, 50% N(2)O concentration, and again postoperatively. In addition, anxiety levels and neuromuscular coordination were recorded at the respective intervals. RESULTS: The results revealed a mean decrease in pulse rate and BP from baseline and an increase in temperature and O(2) saturation during the sedation procedure. The findings were statistically significant. Significant impairment of coordination and psychomotor ability was seen at each step. Anxiety had significantly reduced after the onset of sedation due to the anxiolytic effect of N(2)O. CONCLUSION: N(2)O–O(2) inhalation sedation under different concentrations reduces the anxiety of the patient and produces adequate sedation with vital signs within normal limits along with temporary impairment of psychomotor ability and coordination.