Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2(+) diffuse large B-cell lymphomas

Although oncogenicity of the stem cell regulator SOX9 has been implicated in many solid tumors, its role in lymphomagenesis remains largely unknown. In this study, SOX9 was overexpressed preferentially in a subset of diffuse large B-cell lymphomas (DLBCLs) that harbor IGH-BCL2 translocations. SOX9 p...

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Detalles Bibliográficos
Autores principales: Shen, Yajie, Zhou, Jingqi, Nie, Kui, Cheng, Shuhua, Chen, Zhengming, Wang, Wenhan, Wei, Weiqing, Jiang, Daiji, Peng, Zijing, Ren, Yizhuo, Zhang, Yirong, Fan, Qiuju, Richards, Kristy L., Qi, Yitao, Cheng, Jinke, Tam, Wayne, Ma, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740888/
https://www.ncbi.nlm.nih.gov/pubmed/34624089
http://dx.doi.org/10.1182/blood.2021012327

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