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Binding of AP Endonuclease-1 to G-Quadruplex DNA Depends on the N-Terminal Domain, Mg(2+), and Ionic Strength

[Image: see text] The base excision repair enzyme apurinic/apyrimidinic endonuclease-1 (APE1) is also engaged in transcriptional regulation. APE1 can function in both pathways when the protein binds to a promoter G-quadruplex (G4) bearing an abasic site (modeled with tetrahydrofuran, F) that leads t...

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Detalles Bibliográficos
Autores principales:	Fleming, Aaron M., Howpay Manage, Shereen A., Burrows, Cynthia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740889/ https://www.ncbi.nlm.nih.gov/pubmed/35005714 http://dx.doi.org/10.1021/acsbiomedchemau.1c00031

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