Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis

TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However, the functional relationship between TP53 and ARID1A mutations in the endometrium has not been elucidated. We used genetically en...

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Detalles Bibliográficos
Autores principales: Reske, Jake J., Wilson, Mike R., Holladay, Jeanne, Siwicki, Rebecca A., Skalski, Hilary, Harkins, Shannon, Adams, Marie, Risinger, John I., Hostetter, Galen, Lin, Ken, Chandler, Ronald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741038/
https://www.ncbi.nlm.nih.gov/pubmed/34941867
http://dx.doi.org/10.1371/journal.pgen.1009986

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