Cargando…

The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells

G-1, a GPER1 agonist, was shown to inhibit the growth of castration-resistant mouse xenografts but not their parental androgen-dependent tumors. It is currently unknown how the androgen receptor (AR) represses GPER1 expression. Here, we found that two GPER1 mRNA variants (GPER1v2 and GPER1v4) were t...

Descripción completa

Detalles Bibliográficos
Autores principales:	McDermott, Austin, Kim, KyoungHyun, Kasper, Susan, Ho, Shuk-Mei, Leung, Yuet-Kin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741193/ https://www.ncbi.nlm.nih.gov/pubmed/35018219 http://dx.doi.org/10.18632/oncotarget.28169

Ejemplares similares

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells
por: Hedrick, Erik, et al.
Publicado: (2016)

Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer
por: Khanal, Tilak, et al.
Publicado: (2017)

Mithramycin Targets Sp1 and The Androgen Receptor Transcription Level—Potential Therapeutic Role in Advanced Prostate Cancer
por: Wang, Long G., et al.
Publicado: (2006)

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs
por: Gandhy, Shruti U, et al.
Publicado: (2012)

The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis()()
por: Yang, Won Seok, et al.
Publicado: (2014)

Unique Bisphenol A Transcriptome in Prostate Cancer: Novel Effects on ERβ Expression That Correspond to Androgen Receptor Mutation Status
por: Hess-Wilson, Janet K., et al.
Publicado: (2007)

Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site
por: Eisermann, Kurtis, et al.
Publicado: (2013)

Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC
por: Gandhy, Shruti U., et al.
Publicado: (2015)

An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection
por: Boumber, Yanis A., et al.
Publicado: (2008)

Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist
por: Ding, Qingming, et al.
Publicado: (2022)

Repression of Human T-lymphotropic virus type 1 Long Terminal Repeat sense transcription by Sp1 recruitment to novel Sp1 binding sites
por: Fauquenoy, Sylvain, et al.
Publicado: (2017)

Predictive Value of Sp1/Sp3/FLIP Signature for Prostate Cancer Recurrence
por: Bedolla, Roble G., et al.
Publicado: (2012)

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors
por: Gilmour, Jane, et al.
Publicado: (2019)

Sp1- and Krüppel-like transcription factors
por: Kaczynski, Joanna, et al.
Publicado: (2003)

Reciprocal Role Of DNA Methylation And Sp1 Binding In Ki-67 Gene Transcription
por: Li, Lian-Tao, et al.
Publicado: (2019)

Human SP-D Acts as an Innate Immune Surveillance Molecule Against Androgen-Responsive and Androgen-Resistant Prostate Cancer Cells
por: Thakur, Gargi, et al.
Publicado: (2019)

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter
por: Turrini, Filippo, et al.
Publicado: (2015)

Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene
por: Muckenfuss, Heide, et al.
Publicado: (2007)

Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons
por: Chu, Catherine, et al.
Publicado: (2011)

Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion
por: Leung, Yuet-Kin, et al.
Publicado: (2010)

Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1
por: Yu, Shibing, et al.
Publicado: (2016)

Zearalenone-Induced Interaction between PXR and Sp1 Increases Binding of Sp1 to a Promoter Site of the eNOS, Decreasing Its Transcription and NO Production in BAECs
por: Lee, Hyeon-Ju, et al.
Publicado: (2020)

Transcriptional Activation of Mina by Sp1/3 Factors
por: Lian, Shangli, et al.
Publicado: (2013)

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells
por: Hay, Colin W., et al.
Publicado: (2015)

Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms
por: Thakur, Bhupesh Kumar, et al.
Publicado: (2016)

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer
por: Meng, Ran, et al.
Publicado: (2016)

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
por: Raiber, Eun-Ang, et al.
Publicado: (2012)

Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells
por: Kuan, Chee Sian, et al.
Publicado: (2016)

Decreased Expression of GPER1 Gene and Protein in Goiter
por: Weber, Raquel, et al.
Publicado: (2015)

Serum levels of GPER-1 in euthymic bipolar patients
por: Orhan, Fatma Özlem, et al.
Publicado: (2018)

TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
por: Rajagopalan, Deepa, et al.
Publicado: (2017)

Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer
por: Leung, Yuet-Kin, et al.
Publicado: (2014)

Transcriptional Activation of REST by Sp1 in Huntington's Disease Models
por: Ravache, Myriam, et al.
Publicado: (2010)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis
por: Yang, Hang-Che, et al.
Publicado: (2014)

Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer
por: Leung, Yuet-Kin, et al.
Publicado: (2019)

Pretreatment of dexamethasone before cardiopulmonary bypass upregulates intrahepatic synthesis of IL-10 via the transcription factors Sp1 and Sp3 and CCAAT/enhancer-binding protein
por: Ma, Q, et al.
Publicado: (2005)

Effects of the selective GPER1 agonist G1 on bone growth
por: Iravani, Maryam, et al.
Publicado: (2019)

Association between GPER gene polymorphisms and GPER expression levels with cancer predisposition and progression
por: Ulhaq, Zulvikar Syambani, et al.
Publicado: (2021)

p53 Represses Transcription of RING Finger LIM Domain-Binding Protein RLIM through Sp1
por: Kong, Xiangtao, et al.
Publicado: (2013)

Transcription Factor Sp1 Promotes the Expression of Porcine ROCK1 Gene
por: Zhang, Ruirui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8nbjsr5a5sme6fn07dl58amh0d