Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China

HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed tha...

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Autores principales: Zhang, Zhaoyong, Liu, Wenkuan, Zhang, Shengnan, Wei, Peilan, Zhang, Lu, Chen, Dehui, Qiu, Shuyan, Li, Xiaobo, Zhao, Jingxian, Shi, Yongxia, Zhou, Rong, Wang, Yanqun, Zhao, Jincun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741245/
https://www.ncbi.nlm.nih.gov/pubmed/34907853
http://dx.doi.org/10.1080/22221751.2021.2019560
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author Zhang, Zhaoyong
Liu, Wenkuan
Zhang, Shengnan
Wei, Peilan
Zhang, Lu
Chen, Dehui
Qiu, Shuyan
Li, Xiaobo
Zhao, Jingxian
Shi, Yongxia
Zhou, Rong
Wang, Yanqun
Zhao, Jincun
author_facet Zhang, Zhaoyong
Liu, Wenkuan
Zhang, Shengnan
Wei, Peilan
Zhang, Lu
Chen, Dehui
Qiu, Shuyan
Li, Xiaobo
Zhao, Jingxian
Shi, Yongxia
Zhou, Rong
Wang, Yanqun
Zhao, Jincun
author_sort Zhang, Zhaoyong
collection PubMed
description HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.
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spelling pubmed-87412452022-01-08 Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China Zhang, Zhaoyong Liu, Wenkuan Zhang, Shengnan Wei, Peilan Zhang, Lu Chen, Dehui Qiu, Shuyan Li, Xiaobo Zhao, Jingxian Shi, Yongxia Zhou, Rong Wang, Yanqun Zhao, Jincun Emerg Microbes Infect Coronaviruses HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses. Taylor & Francis 2022-01-04 /pmc/articles/PMC8741245/ /pubmed/34907853 http://dx.doi.org/10.1080/22221751.2021.2019560 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Coronaviruses
Zhang, Zhaoyong
Liu, Wenkuan
Zhang, Shengnan
Wei, Peilan
Zhang, Lu
Chen, Dehui
Qiu, Shuyan
Li, Xiaobo
Zhao, Jingxian
Shi, Yongxia
Zhou, Rong
Wang, Yanqun
Zhao, Jincun
Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
title Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
title_full Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
title_fullStr Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
title_full_unstemmed Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
title_short Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China
title_sort two novel human coronavirus oc43 genotypes circulating in hospitalized children with pneumonia in china
topic Coronaviruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741245/
https://www.ncbi.nlm.nih.gov/pubmed/34907853
http://dx.doi.org/10.1080/22221751.2021.2019560
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