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Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults

BACKGROUND: Body mass index (BMI) is an inadequate marker of obesity, and cannot distinguish between fat mass, fat free mass and distribution of adipose tissue. The purpose of this study was twofold. First, to assess cross-sectional relationship of BMI with fat mass index (FMI), fat free mass index...

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Autores principales: Merchant, Reshma Aziz, Seetharaman, Santhosh, Au, Lydia, Wong, Michael Wai Kit, Wong, Beatrix Ling Ling, Tan, Li Feng, Chen, Matthew Zhixuan, Ng, Shu Ee, Soong, John Tshon Yit, Hui, Richard Jor Yeong, Kwek, Sing Cheer, Morley, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741276/
https://www.ncbi.nlm.nih.gov/pubmed/35002957
http://dx.doi.org/10.3389/fendo.2021.765415
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author Merchant, Reshma Aziz
Seetharaman, Santhosh
Au, Lydia
Wong, Michael Wai Kit
Wong, Beatrix Ling Ling
Tan, Li Feng
Chen, Matthew Zhixuan
Ng, Shu Ee
Soong, John Tshon Yit
Hui, Richard Jor Yeong
Kwek, Sing Cheer
Morley, John E.
author_facet Merchant, Reshma Aziz
Seetharaman, Santhosh
Au, Lydia
Wong, Michael Wai Kit
Wong, Beatrix Ling Ling
Tan, Li Feng
Chen, Matthew Zhixuan
Ng, Shu Ee
Soong, John Tshon Yit
Hui, Richard Jor Yeong
Kwek, Sing Cheer
Morley, John E.
author_sort Merchant, Reshma Aziz
collection PubMed
description BACKGROUND: Body mass index (BMI) is an inadequate marker of obesity, and cannot distinguish between fat mass, fat free mass and distribution of adipose tissue. The purpose of this study was twofold. First, to assess cross-sectional relationship of BMI with fat mass index (FMI), fat free mass index (FFMI) and ratio of fat mass to fat free mass (FM/FFM). Second, to study the association of FMI, FFMI and FM/FFM with physical function including sarcopenia, and cognition in pre-frail older adults. METHODS: Cross-sectional study of 191 pre-frail participants ≥ 65 years, 57.1% females. Data was collected on demographics, cognition [Montreal Cognitive Assessment (MoCA)], function, frailty, calf circumference, handgrip strength (HGS), short physical performance battery (SPPB) and gait speed. Body composition was measured using InBody S10. FMI, FFMI and FM/FFM were classified into tertiles (T1, T2, T3) with T1 classified as lowest and T3 highest tertile respectively and stratified by BMI. RESULTS: Higher FFMI and lower FM/FFM in the high BMI group were associated with better functional outcomes. Prevalence of low muscle mass was higher in the normal BMI group. FMI and FM/FFM were significantly higher in females and FFMI in males with significant gender differences except for FFMI in ≥ 80 years old. Small calf circumference was significantly less prevalent in the highest tertile of FMI, FM/FMI and FFMI. Prevalence of sarcopenic obesity and low physical function (HGS, gait speed and SPPB scores) were significantly higher in the highest FMI and FM/FFM tertile. Highest FFMI tertile group had higher physical function, higher MoCA scores, lower prevalence of sarcopenic obesity and sarcopenia, After adjustment, highest tertile of FFMI was associated with lower odds of sarcopenia especially in the high BMI group. Highest tertile of FM/FFM was associated with higher odds of sarcopenia. Higher BMI was associated with lower odds of sarcopenia. CONCLUSION: FFMI and FM/FFM may be a better predictor of functional outcomes in pre-frail older adults than BMI. Cut-off values for healthy BMI values and role of calf circumference as a screening tool for sarcopenia need to be validated in larger population. Health promotion intervention should focus on FFMI increment.
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spelling pubmed-87412762022-01-08 Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults Merchant, Reshma Aziz Seetharaman, Santhosh Au, Lydia Wong, Michael Wai Kit Wong, Beatrix Ling Ling Tan, Li Feng Chen, Matthew Zhixuan Ng, Shu Ee Soong, John Tshon Yit Hui, Richard Jor Yeong Kwek, Sing Cheer Morley, John E. Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Body mass index (BMI) is an inadequate marker of obesity, and cannot distinguish between fat mass, fat free mass and distribution of adipose tissue. The purpose of this study was twofold. First, to assess cross-sectional relationship of BMI with fat mass index (FMI), fat free mass index (FFMI) and ratio of fat mass to fat free mass (FM/FFM). Second, to study the association of FMI, FFMI and FM/FFM with physical function including sarcopenia, and cognition in pre-frail older adults. METHODS: Cross-sectional study of 191 pre-frail participants ≥ 65 years, 57.1% females. Data was collected on demographics, cognition [Montreal Cognitive Assessment (MoCA)], function, frailty, calf circumference, handgrip strength (HGS), short physical performance battery (SPPB) and gait speed. Body composition was measured using InBody S10. FMI, FFMI and FM/FFM were classified into tertiles (T1, T2, T3) with T1 classified as lowest and T3 highest tertile respectively and stratified by BMI. RESULTS: Higher FFMI and lower FM/FFM in the high BMI group were associated with better functional outcomes. Prevalence of low muscle mass was higher in the normal BMI group. FMI and FM/FFM were significantly higher in females and FFMI in males with significant gender differences except for FFMI in ≥ 80 years old. Small calf circumference was significantly less prevalent in the highest tertile of FMI, FM/FMI and FFMI. Prevalence of sarcopenic obesity and low physical function (HGS, gait speed and SPPB scores) were significantly higher in the highest FMI and FM/FFM tertile. Highest FFMI tertile group had higher physical function, higher MoCA scores, lower prevalence of sarcopenic obesity and sarcopenia, After adjustment, highest tertile of FFMI was associated with lower odds of sarcopenia especially in the high BMI group. Highest tertile of FM/FFM was associated with higher odds of sarcopenia. Higher BMI was associated with lower odds of sarcopenia. CONCLUSION: FFMI and FM/FFM may be a better predictor of functional outcomes in pre-frail older adults than BMI. Cut-off values for healthy BMI values and role of calf circumference as a screening tool for sarcopenia need to be validated in larger population. Health promotion intervention should focus on FFMI increment. Frontiers Media S.A. 2021-12-24 /pmc/articles/PMC8741276/ /pubmed/35002957 http://dx.doi.org/10.3389/fendo.2021.765415 Text en Copyright © 2021 Merchant, Seetharaman, Au, Wong, Wong, Tan, Chen, Ng, Soong, Hui, Kwek and Morley https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Merchant, Reshma Aziz
Seetharaman, Santhosh
Au, Lydia
Wong, Michael Wai Kit
Wong, Beatrix Ling Ling
Tan, Li Feng
Chen, Matthew Zhixuan
Ng, Shu Ee
Soong, John Tshon Yit
Hui, Richard Jor Yeong
Kwek, Sing Cheer
Morley, John E.
Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults
title Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults
title_full Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults
title_fullStr Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults
title_full_unstemmed Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults
title_short Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults
title_sort relationship of fat mass index and fat free mass index with body mass index and association with function, cognition and sarcopenia in pre-frail older adults
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741276/
https://www.ncbi.nlm.nih.gov/pubmed/35002957
http://dx.doi.org/10.3389/fendo.2021.765415
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