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UV and violet light can Neutralize SARS-CoV-2 Infectivity

We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10...

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Autores principales: Biasin, Mara, Strizzi, Sergio, Bianco, Andrea, Macchi, Alberto, Utyro, Olga, Pareschi, Giovanni, Loffreda, Alessia, Cavalleri, Adalberto, Lualdi, Manuela, Trabattoni, Daria, Tacchetti, Carlo, Mazza, Davide, Clerici, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741330/
https://www.ncbi.nlm.nih.gov/pubmed/35036965
http://dx.doi.org/10.1016/j.jpap.2021.100107
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author Biasin, Mara
Strizzi, Sergio
Bianco, Andrea
Macchi, Alberto
Utyro, Olga
Pareschi, Giovanni
Loffreda, Alessia
Cavalleri, Adalberto
Lualdi, Manuela
Trabattoni, Daria
Tacchetti, Carlo
Mazza, Davide
Clerici, Mario
author_facet Biasin, Mara
Strizzi, Sergio
Bianco, Andrea
Macchi, Alberto
Utyro, Olga
Pareschi, Giovanni
Loffreda, Alessia
Cavalleri, Adalberto
Lualdi, Manuela
Trabattoni, Daria
Tacchetti, Carlo
Mazza, Davide
Clerici, Mario
author_sort Biasin, Mara
collection PubMed
description We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10(4) times less efficient than UV-C light. Moreover, by qPCR (quantitative Polymerase chain reaction) and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients can be completely inactivated by the long UV-wavelengths corresponding to UV-A and UV-B solar irradiation. The comparison of the UV action spectrum on SARS-CoV-2 to previous results obtained on other pathogens suggests that RNA viruses might be particularly sensitive to long UV wavelengths. Our data extend previous results showing that SARS-CoV-2 is highly susceptible to UV light and offer an explanation to the reduced incidence of SARS-CoV-2 infection seen in the summer season.
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spelling pubmed-87413302022-01-10 UV and violet light can Neutralize SARS-CoV-2 Infectivity Biasin, Mara Strizzi, Sergio Bianco, Andrea Macchi, Alberto Utyro, Olga Pareschi, Giovanni Loffreda, Alessia Cavalleri, Adalberto Lualdi, Manuela Trabattoni, Daria Tacchetti, Carlo Mazza, Davide Clerici, Mario J Photochem Photobiol Article We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10(4) times less efficient than UV-C light. Moreover, by qPCR (quantitative Polymerase chain reaction) and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients can be completely inactivated by the long UV-wavelengths corresponding to UV-A and UV-B solar irradiation. The comparison of the UV action spectrum on SARS-CoV-2 to previous results obtained on other pathogens suggests that RNA viruses might be particularly sensitive to long UV wavelengths. Our data extend previous results showing that SARS-CoV-2 is highly susceptible to UV light and offer an explanation to the reduced incidence of SARS-CoV-2 infection seen in the summer season. The Authors. Published by Elsevier B.V. 2022-06 2022-01-08 /pmc/articles/PMC8741330/ /pubmed/35036965 http://dx.doi.org/10.1016/j.jpap.2021.100107 Text en © 2022 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Biasin, Mara
Strizzi, Sergio
Bianco, Andrea
Macchi, Alberto
Utyro, Olga
Pareschi, Giovanni
Loffreda, Alessia
Cavalleri, Adalberto
Lualdi, Manuela
Trabattoni, Daria
Tacchetti, Carlo
Mazza, Davide
Clerici, Mario
UV and violet light can Neutralize SARS-CoV-2 Infectivity
title UV and violet light can Neutralize SARS-CoV-2 Infectivity
title_full UV and violet light can Neutralize SARS-CoV-2 Infectivity
title_fullStr UV and violet light can Neutralize SARS-CoV-2 Infectivity
title_full_unstemmed UV and violet light can Neutralize SARS-CoV-2 Infectivity
title_short UV and violet light can Neutralize SARS-CoV-2 Infectivity
title_sort uv and violet light can neutralize sars-cov-2 infectivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741330/
https://www.ncbi.nlm.nih.gov/pubmed/35036965
http://dx.doi.org/10.1016/j.jpap.2021.100107
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