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Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus
Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741389/ https://www.ncbi.nlm.nih.gov/pubmed/35003251 http://dx.doi.org/10.1155/2021/2804533 |
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author | Hu, Haimeng Lyu, Yining Li, Shihong Yuan, Zheng Ye, Chuntao Han, Zhao Lin, Guangwu |
author_facet | Hu, Haimeng Lyu, Yining Li, Shihong Yuan, Zheng Ye, Chuntao Han, Zhao Lin, Guangwu |
author_sort | Hu, Haimeng |
collection | PubMed |
description | Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to test whether there is a change in intrinsic functional connectivity (FC) patterns between the DAN and other brain regions in tinnitus patients. Thirty-one patients with persistent tinnitus and thirty-three healthy controls were enrolled in this study. A group independent component analysis (ICA), degree centrality (DC) analysis, and seed-based FC analysis were conducted. In the group ICA, the tinnitus patients showed increased connectivity in the left superior parietal gyrus in the DAN compared to the healthy controls. Compared with the healthy controls, the tinnitus patients showed increased DC in the left inferior parietal gyrus and decreased DC in the left precuneus within the DAN. The clusters within the DAN with significant differences in the ICA or DC analysis between the tinnitus patients and the healthy controls were selected as regions of interest (ROIs) for seeds. The tinnitus patients exhibited significantly increased FC from the left superior parietal gyrus to several brain regions, including the left inferior parietal gyrus, the left superior marginal gyrus, and the right superior frontal gyrus, and decreased FC to the right anterior cingulate cortex. The tinnitus patients exhibited decreased FC from the left precuneus to the left inferior occipital gyrus, left calcarine cortex, and left superior frontal gyrus compared with the healthy controls. The findings of this study show that compared with healthy controls, tinnitus patients have altered functional connections not only within the DAN but also between the DAN and other brain regions. These results suggest that it may be possible to improve the disturbance and influence of tinnitus by regulating the DAN. |
format | Online Article Text |
id | pubmed-8741389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87413892022-01-08 Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus Hu, Haimeng Lyu, Yining Li, Shihong Yuan, Zheng Ye, Chuntao Han, Zhao Lin, Guangwu Neural Plast Research Article Previous functional magnetic resonance imaging (fMRI) analyses have shown that the dorsal attention network (DAN) is involved in the pathophysiological changes of tinnitus, but few relevant studies have been conducted, and the conclusions to date are not uniform. The purpose of this research was to test whether there is a change in intrinsic functional connectivity (FC) patterns between the DAN and other brain regions in tinnitus patients. Thirty-one patients with persistent tinnitus and thirty-three healthy controls were enrolled in this study. A group independent component analysis (ICA), degree centrality (DC) analysis, and seed-based FC analysis were conducted. In the group ICA, the tinnitus patients showed increased connectivity in the left superior parietal gyrus in the DAN compared to the healthy controls. Compared with the healthy controls, the tinnitus patients showed increased DC in the left inferior parietal gyrus and decreased DC in the left precuneus within the DAN. The clusters within the DAN with significant differences in the ICA or DC analysis between the tinnitus patients and the healthy controls were selected as regions of interest (ROIs) for seeds. The tinnitus patients exhibited significantly increased FC from the left superior parietal gyrus to several brain regions, including the left inferior parietal gyrus, the left superior marginal gyrus, and the right superior frontal gyrus, and decreased FC to the right anterior cingulate cortex. The tinnitus patients exhibited decreased FC from the left precuneus to the left inferior occipital gyrus, left calcarine cortex, and left superior frontal gyrus compared with the healthy controls. The findings of this study show that compared with healthy controls, tinnitus patients have altered functional connections not only within the DAN but also between the DAN and other brain regions. These results suggest that it may be possible to improve the disturbance and influence of tinnitus by regulating the DAN. Hindawi 2021-12-31 /pmc/articles/PMC8741389/ /pubmed/35003251 http://dx.doi.org/10.1155/2021/2804533 Text en Copyright © 2021 Haimeng Hu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hu, Haimeng Lyu, Yining Li, Shihong Yuan, Zheng Ye, Chuntao Han, Zhao Lin, Guangwu Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
title | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
title_full | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
title_fullStr | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
title_full_unstemmed | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
title_short | Aberrant Resting-State Functional Connectivity of the Dorsal Attention Network in Tinnitus |
title_sort | aberrant resting-state functional connectivity of the dorsal attention network in tinnitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741389/ https://www.ncbi.nlm.nih.gov/pubmed/35003251 http://dx.doi.org/10.1155/2021/2804533 |
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