Histone modifications in neurodifferentiation of embryonic stem cells

Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication. Cellular lineage differentiation involves large-scale intracellular signaling and extracellular context. In particular, histone modifications play...

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Detalles Bibliográficos
Autores principales: Huang, Min, Xiao, Xiaoxiao, Ji, Guanxu, Wu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741459/
https://www.ncbi.nlm.nih.gov/pubmed/35028451
http://dx.doi.org/10.1016/j.heliyon.2021.e08664
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author Huang, Min
Xiao, Xiaoxiao
Ji, Guanxu
Wu, Qiang
author_facet Huang, Min
Xiao, Xiaoxiao
Ji, Guanxu
Wu, Qiang
author_sort Huang, Min
collection PubMed
description Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication. Cellular lineage differentiation involves large-scale intracellular signaling and extracellular context. In particular, histone modifications play instructive and programmatic roles in central nervous system development. Deciphering functions of histone could offer feasible molecular strategies for neural diseases caused by histone modifications. Here, we review recent advances of in vitro and in vivo studies on histone modifications in neural differentiation.
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spelling pubmed-87414592022-01-12 Histone modifications in neurodifferentiation of embryonic stem cells Huang, Min Xiao, Xiaoxiao Ji, Guanxu Wu, Qiang Heliyon Review Article Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication. Cellular lineage differentiation involves large-scale intracellular signaling and extracellular context. In particular, histone modifications play instructive and programmatic roles in central nervous system development. Deciphering functions of histone could offer feasible molecular strategies for neural diseases caused by histone modifications. Here, we review recent advances of in vitro and in vivo studies on histone modifications in neural differentiation. Elsevier 2021-12-23 /pmc/articles/PMC8741459/ /pubmed/35028451 http://dx.doi.org/10.1016/j.heliyon.2021.e08664 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Huang, Min
Xiao, Xiaoxiao
Ji, Guanxu
Wu, Qiang
Histone modifications in neurodifferentiation of embryonic stem cells
title Histone modifications in neurodifferentiation of embryonic stem cells
title_full Histone modifications in neurodifferentiation of embryonic stem cells
title_fullStr Histone modifications in neurodifferentiation of embryonic stem cells
title_full_unstemmed Histone modifications in neurodifferentiation of embryonic stem cells
title_short Histone modifications in neurodifferentiation of embryonic stem cells
title_sort histone modifications in neurodifferentiation of embryonic stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741459/
https://www.ncbi.nlm.nih.gov/pubmed/35028451
http://dx.doi.org/10.1016/j.heliyon.2021.e08664
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AT jiguanxu histonemodificationsinneurodifferentiationofembryonicstemcells
AT wuqiang histonemodificationsinneurodifferentiationofembryonicstemcells

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