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Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease

Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liv...

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Autores principales: Zhu, Mei-Ning, Zhao, Cui-Zhu, Wang, Chong-Zhi, Rao, Jian-Bo, Qiu, Yong-Wei, Gao, Yan-Ping, Wang, Xiao-Yun, Zhang, Ya-Mei, Wu, Guang, Chen, Jie, Ma, Qin-Ge, Zhong, Guo-Yue, Wei, Rong-Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741472/
https://www.ncbi.nlm.nih.gov/pubmed/35028346
http://dx.doi.org/10.1016/j.dib.2021.107773
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author Zhu, Mei-Ning
Zhao, Cui-Zhu
Wang, Chong-Zhi
Rao, Jian-Bo
Qiu, Yong-Wei
Gao, Yan-Ping
Wang, Xiao-Yun
Zhang, Ya-Mei
Wu, Guang
Chen, Jie
Ma, Qin-Ge
Zhong, Guo-Yue
Wei, Rong-Rui
author_facet Zhu, Mei-Ning
Zhao, Cui-Zhu
Wang, Chong-Zhi
Rao, Jian-Bo
Qiu, Yong-Wei
Gao, Yan-Ping
Wang, Xiao-Yun
Zhang, Ya-Mei
Wu, Guang
Chen, Jie
Ma, Qin-Ge
Zhong, Guo-Yue
Wei, Rong-Rui
author_sort Zhu, Mei-Ning
collection PubMed
description Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liver lipid accumulation caused by a high-fat, high-fructose, high-cholesterol diet. However, it is not clear what changes have taken place in the process of liver lipid metabolism after HBMPWE administration. To fill this knowledge gap and to support the findings published in the companion research article entitled “Highland Barley Monascus purpureus Went Extract Ameliorates High-Fat, High-Fructose, High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism in Golden Hamsters” [1], we provided important information related to the liver differential metabolites and identified twenty-one differential metabolites of liver metabolism. In the model group, the levels of lactate, linoleic acid, and malic acid increased significantly. After HBMPWE treatment, the expressions of these metabolites reduced significantly. Therefore, these liver differential metabolites could be used as biological signatures reflecting the severity of NAFLD and HBMPWE treatment outcomes.
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spelling pubmed-87414722022-01-12 Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease Zhu, Mei-Ning Zhao, Cui-Zhu Wang, Chong-Zhi Rao, Jian-Bo Qiu, Yong-Wei Gao, Yan-Ping Wang, Xiao-Yun Zhang, Ya-Mei Wu, Guang Chen, Jie Ma, Qin-Ge Zhong, Guo-Yue Wei, Rong-Rui Data Brief Data Article Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liver lipid accumulation caused by a high-fat, high-fructose, high-cholesterol diet. However, it is not clear what changes have taken place in the process of liver lipid metabolism after HBMPWE administration. To fill this knowledge gap and to support the findings published in the companion research article entitled “Highland Barley Monascus purpureus Went Extract Ameliorates High-Fat, High-Fructose, High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism in Golden Hamsters” [1], we provided important information related to the liver differential metabolites and identified twenty-one differential metabolites of liver metabolism. In the model group, the levels of lactate, linoleic acid, and malic acid increased significantly. After HBMPWE treatment, the expressions of these metabolites reduced significantly. Therefore, these liver differential metabolites could be used as biological signatures reflecting the severity of NAFLD and HBMPWE treatment outcomes. Elsevier 2021-12-30 /pmc/articles/PMC8741472/ /pubmed/35028346 http://dx.doi.org/10.1016/j.dib.2021.107773 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data Article
Zhu, Mei-Ning
Zhao, Cui-Zhu
Wang, Chong-Zhi
Rao, Jian-Bo
Qiu, Yong-Wei
Gao, Yan-Ping
Wang, Xiao-Yun
Zhang, Ya-Mei
Wu, Guang
Chen, Jie
Ma, Qin-Ge
Zhong, Guo-Yue
Wei, Rong-Rui
Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
title Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
title_full Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
title_fullStr Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
title_full_unstemmed Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
title_short Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
title_sort dataset for liver metabolomic profile of highland barley monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741472/
https://www.ncbi.nlm.nih.gov/pubmed/35028346
http://dx.doi.org/10.1016/j.dib.2021.107773
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