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Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liv...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741472/ https://www.ncbi.nlm.nih.gov/pubmed/35028346 http://dx.doi.org/10.1016/j.dib.2021.107773 |
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author | Zhu, Mei-Ning Zhao, Cui-Zhu Wang, Chong-Zhi Rao, Jian-Bo Qiu, Yong-Wei Gao, Yan-Ping Wang, Xiao-Yun Zhang, Ya-Mei Wu, Guang Chen, Jie Ma, Qin-Ge Zhong, Guo-Yue Wei, Rong-Rui |
author_facet | Zhu, Mei-Ning Zhao, Cui-Zhu Wang, Chong-Zhi Rao, Jian-Bo Qiu, Yong-Wei Gao, Yan-Ping Wang, Xiao-Yun Zhang, Ya-Mei Wu, Guang Chen, Jie Ma, Qin-Ge Zhong, Guo-Yue Wei, Rong-Rui |
author_sort | Zhu, Mei-Ning |
collection | PubMed |
description | Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liver lipid accumulation caused by a high-fat, high-fructose, high-cholesterol diet. However, it is not clear what changes have taken place in the process of liver lipid metabolism after HBMPWE administration. To fill this knowledge gap and to support the findings published in the companion research article entitled “Highland Barley Monascus purpureus Went Extract Ameliorates High-Fat, High-Fructose, High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism in Golden Hamsters” [1], we provided important information related to the liver differential metabolites and identified twenty-one differential metabolites of liver metabolism. In the model group, the levels of lactate, linoleic acid, and malic acid increased significantly. After HBMPWE treatment, the expressions of these metabolites reduced significantly. Therefore, these liver differential metabolites could be used as biological signatures reflecting the severity of NAFLD and HBMPWE treatment outcomes. |
format | Online Article Text |
id | pubmed-8741472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-87414722022-01-12 Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease Zhu, Mei-Ning Zhao, Cui-Zhu Wang, Chong-Zhi Rao, Jian-Bo Qiu, Yong-Wei Gao, Yan-Ping Wang, Xiao-Yun Zhang, Ya-Mei Wu, Guang Chen, Jie Ma, Qin-Ge Zhong, Guo-Yue Wei, Rong-Rui Data Brief Data Article Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liver lipid accumulation caused by a high-fat, high-fructose, high-cholesterol diet. However, it is not clear what changes have taken place in the process of liver lipid metabolism after HBMPWE administration. To fill this knowledge gap and to support the findings published in the companion research article entitled “Highland Barley Monascus purpureus Went Extract Ameliorates High-Fat, High-Fructose, High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism in Golden Hamsters” [1], we provided important information related to the liver differential metabolites and identified twenty-one differential metabolites of liver metabolism. In the model group, the levels of lactate, linoleic acid, and malic acid increased significantly. After HBMPWE treatment, the expressions of these metabolites reduced significantly. Therefore, these liver differential metabolites could be used as biological signatures reflecting the severity of NAFLD and HBMPWE treatment outcomes. Elsevier 2021-12-30 /pmc/articles/PMC8741472/ /pubmed/35028346 http://dx.doi.org/10.1016/j.dib.2021.107773 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Data Article Zhu, Mei-Ning Zhao, Cui-Zhu Wang, Chong-Zhi Rao, Jian-Bo Qiu, Yong-Wei Gao, Yan-Ping Wang, Xiao-Yun Zhang, Ya-Mei Wu, Guang Chen, Jie Ma, Qin-Ge Zhong, Guo-Yue Wei, Rong-Rui Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
title | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
title_full | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
title_fullStr | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
title_full_unstemmed | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
title_short | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
title_sort | dataset for liver metabolomic profile of highland barley monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease |
topic | Data Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741472/ https://www.ncbi.nlm.nih.gov/pubmed/35028346 http://dx.doi.org/10.1016/j.dib.2021.107773 |
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