The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection

We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma wer...

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Autores principales: Jafarova, S. H., Adnaev, S. A., Guliyeva, R. T., Jafar, N. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
General Pathology and Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741565/
https://www.ncbi.nlm.nih.gov/pubmed/34997875
http://dx.doi.org/10.1007/s10517-022-05377-7
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author Jafarova, S. H.
Adnaev, S. A.
Guliyeva, R. T.
Jafar, N. H.
author_facet Jafarova, S. H.
Adnaev, S. A.
Guliyeva, R. T.
Jafar, N. H.
author_sort Jafarova, S. H.
collection PubMed
description We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na(+)/K(+)-ATPase activity and significant hyponatrenemia. In patients with cardiovascular pathologies and allergy to statins, erythrocyte membranes were most sensitive to a decrease in pH, while erythrocyte membranes of obese patients showed the greatest resistance to low pH and oxidative stress.
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spelling pubmed-87415652022-01-10 The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection Jafarova, S. H. Adnaev, S. A. Guliyeva, R. T. Jafar, N. H. Bull Exp Biol Med General Pathology and Pathophysiology We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na(+)/K(+)-ATPase activity and significant hyponatrenemia. In patients with cardiovascular pathologies and allergy to statins, erythrocyte membranes were most sensitive to a decrease in pH, while erythrocyte membranes of obese patients showed the greatest resistance to low pH and oxidative stress. Springer US 2022-01-08 2022 /pmc/articles/PMC8741565/ /pubmed/34997875 http://dx.doi.org/10.1007/s10517-022-05377-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle General Pathology and Pathophysiology
Jafarova, S. H.
Adnaev, S. A.
Guliyeva, R. T.
Jafar, N. H.
The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
title The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
title_full The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
title_fullStr The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
title_full_unstemmed The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
title_short The Role of Na(+)/K(+)-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection
title_sort role of na(+)/k(+)-atpase in the development of hyponatrenemia under conditions of hypoxic stress in patients with sars-cov-2 infection
topic General Pathology and Pathophysiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741565/
https://www.ncbi.nlm.nih.gov/pubmed/34997875
http://dx.doi.org/10.1007/s10517-022-05377-7
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