Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice

A novel peptide that interferes with the PD-1/PD-L1 immune checkpoint pathway, termed PD-L1 inhibitory peptide 3 (PD-L1ip3), was computationally designed, experimentally validated for its specific binding to PD-L1, and evaluated for its antitumor effects in cell culture and in a mouse colon carcinom...

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Detalles Bibliográficos
Autores principales: Ishiguro, Susumu, Upreti, Deepa, Bassette, Molly, Singam, E.R. Azhagiya, Thakkar, Ravindra, Loyd, Mayme, Inui, Makoto, Comer, Jeffrey, Tamura, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741604/
https://www.ncbi.nlm.nih.gov/pubmed/34990908
http://dx.doi.org/10.1016/j.tranon.2021.101337

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