Analysis of oxidative stress indicators in Polish patients with prostate cancer

The aim of the study was to analyze the activity of antioxidant enzymes (glutathione S-transferase, catalase, superoxide dismutase) and the concentration of malondialdehyde in order to determine the role of detoxification mechanisms in prostate cancer. The activities of superoxide dismutase (SOD), c...

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Autores principales: Drozdz-Afelt, Joanna Maria, Koim-Puchowska, Beata Barbara, Kaminski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741701/
https://www.ncbi.nlm.nih.gov/pubmed/34409535
http://dx.doi.org/10.1007/s11356-021-15922-y
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author Drozdz-Afelt, Joanna Maria
Koim-Puchowska, Beata Barbara
Kaminski, Piotr
author_facet Drozdz-Afelt, Joanna Maria
Koim-Puchowska, Beata Barbara
Kaminski, Piotr
author_sort Drozdz-Afelt, Joanna Maria
collection PubMed
description The aim of the study was to analyze the activity of antioxidant enzymes (glutathione S-transferase, catalase, superoxide dismutase) and the concentration of malondialdehyde in order to determine the role of detoxification mechanisms in prostate cancer. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were measured using ready-made kits; lipid peroxidation intensity was determined by the thiobarbituric acid method. Superoxide dismutase was the only enzyme among antioxidant and detoxification enzymes for which a statistically significant difference in activity was found between the studied groups (1.4 U·ml(−1) in patients vs. 1.6 U·ml(−1) in control). No statistically significant differences were found for GST, CAT or the concentration of MDA between the group of men with prostate cancer and the control group. The lower SOD activity in men with prostate cancer may be due to a deficiency in their antioxidant defense system.
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spelling pubmed-87417012022-01-20 Analysis of oxidative stress indicators in Polish patients with prostate cancer Drozdz-Afelt, Joanna Maria Koim-Puchowska, Beata Barbara Kaminski, Piotr Environ Sci Pollut Res Int Research Article The aim of the study was to analyze the activity of antioxidant enzymes (glutathione S-transferase, catalase, superoxide dismutase) and the concentration of malondialdehyde in order to determine the role of detoxification mechanisms in prostate cancer. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were measured using ready-made kits; lipid peroxidation intensity was determined by the thiobarbituric acid method. Superoxide dismutase was the only enzyme among antioxidant and detoxification enzymes for which a statistically significant difference in activity was found between the studied groups (1.4 U·ml(−1) in patients vs. 1.6 U·ml(−1) in control). No statistically significant differences were found for GST, CAT or the concentration of MDA between the group of men with prostate cancer and the control group. The lower SOD activity in men with prostate cancer may be due to a deficiency in their antioxidant defense system. Springer Berlin Heidelberg 2021-08-19 2022 /pmc/articles/PMC8741701/ /pubmed/34409535 http://dx.doi.org/10.1007/s11356-021-15922-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Drozdz-Afelt, Joanna Maria
Koim-Puchowska, Beata Barbara
Kaminski, Piotr
Analysis of oxidative stress indicators in Polish patients with prostate cancer
title Analysis of oxidative stress indicators in Polish patients with prostate cancer
title_full Analysis of oxidative stress indicators in Polish patients with prostate cancer
title_fullStr Analysis of oxidative stress indicators in Polish patients with prostate cancer
title_full_unstemmed Analysis of oxidative stress indicators in Polish patients with prostate cancer
title_short Analysis of oxidative stress indicators in Polish patients with prostate cancer
title_sort analysis of oxidative stress indicators in polish patients with prostate cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741701/
https://www.ncbi.nlm.nih.gov/pubmed/34409535
http://dx.doi.org/10.1007/s11356-021-15922-y
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