Cargando…

Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel

Chimeric antigen receptor (CAR) T cell–related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T‐cell follow...

Descripción completa

Detalles Bibliográficos
Autores principales: Martín‐Rojas, Reyes Maria, Gómez‐Centurión, Ignacio, Bailén, Rebeca, Bastos, Mariana, Diaz‐Crespo, Francisco, Carbonell, Diego, Correa‐Rocha, Rafael, Pion, Marjorie, Muñoz, Cristina, Sancho, Milagros, Gómez Fernández, Isabel, Oarbeascoa, Gillen, Pérez‐Corral, Ana, Martínez‐Laperche, Carolina, Anguita, Javier, Buño, Ismael, Menárguez, Javier, Díez‐Martín, Jose Luis, Kwon, Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741874/
https://www.ncbi.nlm.nih.gov/pubmed/35028140
http://dx.doi.org/10.1002/ccr3.5209
_version_ 1784629586219237376
author Martín‐Rojas, Reyes Maria
Gómez‐Centurión, Ignacio
Bailén, Rebeca
Bastos, Mariana
Diaz‐Crespo, Francisco
Carbonell, Diego
Correa‐Rocha, Rafael
Pion, Marjorie
Muñoz, Cristina
Sancho, Milagros
Gómez Fernández, Isabel
Oarbeascoa, Gillen
Pérez‐Corral, Ana
Martínez‐Laperche, Carolina
Anguita, Javier
Buño, Ismael
Menárguez, Javier
Díez‐Martín, Jose Luis
Kwon, Mi
author_facet Martín‐Rojas, Reyes Maria
Gómez‐Centurión, Ignacio
Bailén, Rebeca
Bastos, Mariana
Diaz‐Crespo, Francisco
Carbonell, Diego
Correa‐Rocha, Rafael
Pion, Marjorie
Muñoz, Cristina
Sancho, Milagros
Gómez Fernández, Isabel
Oarbeascoa, Gillen
Pérez‐Corral, Ana
Martínez‐Laperche, Carolina
Anguita, Javier
Buño, Ismael
Menárguez, Javier
Díez‐Martín, Jose Luis
Kwon, Mi
author_sort Martín‐Rojas, Reyes Maria
collection PubMed
description Chimeric antigen receptor (CAR) T cell–related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T‐cell follow‐up, allows a more precise management of this complication.
format Online
Article
Text
id pubmed-8741874
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-87418742022-01-12 Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel Martín‐Rojas, Reyes Maria Gómez‐Centurión, Ignacio Bailén, Rebeca Bastos, Mariana Diaz‐Crespo, Francisco Carbonell, Diego Correa‐Rocha, Rafael Pion, Marjorie Muñoz, Cristina Sancho, Milagros Gómez Fernández, Isabel Oarbeascoa, Gillen Pérez‐Corral, Ana Martínez‐Laperche, Carolina Anguita, Javier Buño, Ismael Menárguez, Javier Díez‐Martín, Jose Luis Kwon, Mi Clin Case Rep Case Report Chimeric antigen receptor (CAR) T cell–related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T‐cell follow‐up, allows a more precise management of this complication. John Wiley and Sons Inc. 2022-01-07 /pmc/articles/PMC8741874/ /pubmed/35028140 http://dx.doi.org/10.1002/ccr3.5209 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Martín‐Rojas, Reyes Maria
Gómez‐Centurión, Ignacio
Bailén, Rebeca
Bastos, Mariana
Diaz‐Crespo, Francisco
Carbonell, Diego
Correa‐Rocha, Rafael
Pion, Marjorie
Muñoz, Cristina
Sancho, Milagros
Gómez Fernández, Isabel
Oarbeascoa, Gillen
Pérez‐Corral, Ana
Martínez‐Laperche, Carolina
Anguita, Javier
Buño, Ismael
Menárguez, Javier
Díez‐Martín, Jose Luis
Kwon, Mi
Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel
title Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel
title_full Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel
title_fullStr Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel
title_full_unstemmed Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel
title_short Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel
title_sort hemophagocytic lymphohistiocytosis/macrophage activation syndrome (hlh/mas) following treatment with tisagenlecleucel
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741874/
https://www.ncbi.nlm.nih.gov/pubmed/35028140
http://dx.doi.org/10.1002/ccr3.5209
work_keys_str_mv AT martinrojasreyesmaria hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT gomezcenturionignacio hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT bailenrebeca hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT bastosmariana hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT diazcrespofrancisco hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT carbonelldiego hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT correarocharafael hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT pionmarjorie hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT munozcristina hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT sanchomilagros hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT gomezfernandezisabel hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT oarbeascoagillen hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT perezcorralana hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT martinezlaperchecarolina hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT anguitajavier hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT bunoismael hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT menarguezjavier hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT diezmartinjoseluis hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel
AT kwonmi hemophagocyticlymphohistiocytosismacrophageactivationsyndromehlhmasfollowingtreatmentwithtisagenlecleucel