Holotoxin disassembly by protein disulfide isomerase is less efficient for Escherichia coli heat-labile enterotoxin than cholera toxin

Cholera toxin (CT) and Escherichia coli heat-labile enterotoxin (LT) are structurally similar AB(5)-type protein toxins. They move from the cell surface to the endoplasmic reticulum where the A1 catalytic subunit is separated from its holotoxin by protein disulfide isomerase (PDI), thus allowing the...

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Detalles Bibliográficos
Autores principales: Serrano, Albert, Guyette, Jessica L., Heim, Joel B., Taylor, Michael, Cherubin, Patrick, Krengel, Ute, Teter, Ken, Tatulian, Suren A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741891/
https://www.ncbi.nlm.nih.gov/pubmed/34997016
http://dx.doi.org/10.1038/s41598-021-03939-9

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