Cargando…

Comprehensive quantitative analysis of alternative splicing variants reveals the HNF1B mRNA splicing pattern in various tumour and non-tumour tissues

Hepatocyte nuclear factor-1-beta (HNF1B) is a transcription factor and putative biomarker of solid tumours. Recently, we have revealed a variety of HNF1B mRNA alternative splicing variants (ASVs) with unknown, but potentially regulatory, functions. The aim of our work was to quantify the most common...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hojny, Jan, Michalkova, Romana, Krkavcova, Eva, Bui, Quang Hiep, Bartu, Michaela, Nemejcova, Kristyna, Kalousova, Marta, Kleiblova, Petra, Dundr, Pavel, Struzinska, Ivana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741901/ https://www.ncbi.nlm.nih.gov/pubmed/34997048 http://dx.doi.org/10.1038/s41598-021-03989-z

Ejemplares similares

Analysis of expression, epigenetic, and genetic changes of HNF1B in 130 kidney tumours
por: Bártů, Michaela, et al.
Publicado: (2020)

Identification of novel HNF1B mRNA splicing variants and their qualitative and semi-quantitative profile in selected healthy and tumour tissues
por: Hojny, Jan, et al.
Publicado: (2020)

A comprehensive analysis of the expression, epigenetic and genetic changes of HNF1B and ECI2 in 122 cases of high-grade serous ovarian carcinoma
por: Němejcová, Kristýna, et al.
Publicado: (2021)

HNF1B, EZH2 and ECI2 in prostate carcinoma. Molecular, immunohistochemical and clinico-pathological study
por: Dundr, Pavel, et al.
Publicado: (2020)

Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis
por: Dundr, Pavel, et al.
Publicado: (2020)

Desmoplastic Small Round Cell Tumor of the Uterus: A Report of Molecularly Confirmed Case with EWSR1-WT1 Fusion
por: Dundr, Pavel, et al.
Publicado: (2022)

Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics
por: Dundr, Pavel, et al.
Publicado: (2021)

A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations
por: Stružinská, Ivana, et al.
Publicado: (2023)

A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants
por: Ticha, Ivana, et al.
Publicado: (2019)

Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases
por: Hájková, Nikola, et al.
Publicado: (2019)

A comprehensive immunohistochemical analysis of 26 markers in 250 cases of serous ovarian tumors
por: Němejcová, Kristýna, et al.
Publicado: (2023)

Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases
por: Němejcová, Kristýna, et al.
Publicado: (2015)

Germline mutation in the TP53 gene in uveal melanoma
por: Hajkova, Nikola, et al.
Publicado: (2018)

Clear cell stromal tumor of the lung with multinucleated giant cells: a report of a case with YAP1-TFE3 fusion
por: Jakša, Radek, et al.
Publicado: (2023)

A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors
por: Němejcová, Kristýna, et al.
Publicado: (2023)

Tumour-free distance: a novel prognostic marker in patients with early-stage cervical cancer treated by primary surgery
por: Cibula, David, et al.
Publicado: (2020)

The role of c-FLIP splice variants in urothelial tumours
por: Ewald, F, et al.
Publicado: (2011)

Alternative RNA splicing in tumour heterogeneity, plasticity and therapy
por: Öther-Gee Pohl, Sebastian, et al.
Publicado: (2022)

The Diagnostic Accuracy of Ultrasound in Assessment of Myometrial Invasion in Endometrial Cancer: Subjective Assessment versus Objective Techniques
por: Frühauf, Filip, et al.
Publicado: (2017)

The Abscopal Effect in the Era of Checkpoint Inhibitors
por: Kodet, Ondřej, et al.
Publicado: (2021)

Inhalation of ZnO Nanoparticles: Splice Junction Expression and Alternative Splicing in Mice
por: Rossner, Pavel, et al.
Publicado: (2019)

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor
por: Legge, Danny, et al.
Publicado: (2021)

Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy
por: Abou-Fayçal, Cherine, et al.
Publicado: (2017)

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
por: Wang, Bi-Dar, et al.
Publicado: (2017)

Identification of tumour immune microenvironment-related alternative splicing events for the prognostication of pancreatic adenocarcinoma
por: Chen, Bo, et al.
Publicado: (2021)

A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
por: Thuesen, Anne Cathrine Baun, et al.
Publicado: (2022)

Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer.
por: Gotley, D. C., et al.
Publicado: (1996)

CCK(2) receptor splice variant with intron 4 retention in human gastrointestinal and lung tumours
por: Körner, Meike, et al.
Publicado: (2010)

Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
por: Wang, Bi-Dar, et al.
Publicado: (2017)

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
por: Qi, Yangfan, et al.
Publicado: (2016)

ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer
por: Melekhova, Anna, et al.
Publicado: (2021)

Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma
por: Havranek, Ondrej, et al.
Publicado: (2015)

Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype
por: Barathova, M, et al.
Publicado: (2008)

A Novel Tissue and Stem Cell Specific TERF1 Splice Variant Is Downregulated in Tumour Cells
por: Morcos, Yousef Ashraf Tawfik, et al.
Publicado: (2019)

GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence
por: Uceda-Castro, Rebeca, et al.
Publicado: (2022)

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
por: Hall, Adam E., et al.
Publicado: (2022)

Accuracy of Various MRI Sequences in Determining the Tumour Margin in Musculoskeletal Tumours
por: Putta, Tharani, et al.
Publicado: (2016)

Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression
por: Pospisil, Heike, et al.
Publicado: (2006)

Alternative promoter usage and mRNA splicing pathways for parathyroid hormone-related protein in normal tissues and tumours.
por: Southby, J., et al.
Publicado: (1995)

Splicing and alternative splicing in rice and humans
por: E, Zhiguo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ohd1hn4ql479ngn0vt9016b249