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Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm

Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD in rats. Excessive mechanical stra...

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Detalles Bibliográficos
Autores principales:	Ding, Sheng-Long, Zhang, Tai-Wei, Zhang, Qi-Chen, Ding, Wang, Li, Ze-Fang, Han, Guan-Jie, Bai, Jin-Song, Li, Xi-Lei, Dong, Jian, Wang, Hui-Ren, Jiang, Li-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741925/ https://www.ncbi.nlm.nih.gov/pubmed/34934193 http://dx.doi.org/10.1038/s12276-021-00716-6

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