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Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration

To find baseline predictors for subretinal fibrosis (SF) in neovascular age-related macular degeneration (nAMD). Forty-five eyes of 45 participants with treatment-naïve nAMD were consecutively enrolled and treated according to a standardized treat-and-extend protocol. Spectral-domain optical coheren...

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Autores principales: Roberts, Philipp K., Schranz, Markus, Motschi, Alice, Desissaire, Sylvia, Hacker, Valentin, Pircher, Michael, Sacu, Stefan, Buehl, Wolf, Hitzenberger, Christoph K., Schmidt-Erfurth, Ursula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741927/
https://www.ncbi.nlm.nih.gov/pubmed/34996934
http://dx.doi.org/10.1038/s41598-021-03716-8
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author Roberts, Philipp K.
Schranz, Markus
Motschi, Alice
Desissaire, Sylvia
Hacker, Valentin
Pircher, Michael
Sacu, Stefan
Buehl, Wolf
Hitzenberger, Christoph K.
Schmidt-Erfurth, Ursula M.
author_facet Roberts, Philipp K.
Schranz, Markus
Motschi, Alice
Desissaire, Sylvia
Hacker, Valentin
Pircher, Michael
Sacu, Stefan
Buehl, Wolf
Hitzenberger, Christoph K.
Schmidt-Erfurth, Ursula M.
author_sort Roberts, Philipp K.
collection PubMed
description To find baseline predictors for subretinal fibrosis (SF) in neovascular age-related macular degeneration (nAMD). Forty-five eyes of 45 participants with treatment-naïve nAMD were consecutively enrolled and treated according to a standardized treat-and-extend protocol. Spectral-domain optical coherence tomography (OCT), color fundus photography and fluorescein angiography as well as novel imaging modalities polarization-sensitive OCT and OCT angiography (OCTA) were performed to detect SF after 1 year and find baseline predictors for SF development. Baseline OCTA scans were evaluated for quantitative features such as lesion area, vessel area, vessel junctions, vessel length, vessel endpoints and mean lacunarity. Additionally, the type of macular neovascularization, the presence of subretinal fluid, intraretinal fluid (IRF), subretinal hyperreflective material (SHRM), retinal hemorrhage as well as best-corrected visual acuity (BCVA) were evaluated. After 12 months 8 eyes (18%) developed SF. Eyes with SF had worse baseline BCVA (p = .001) and a higher prevalence of IRF (p = .014) and SHRM at baseline (p = .017). There was no significant difference in any of the evaluated quantitative OCTA parameters (p > .05) between eyes with and without SF. There were no quantitative baseline microvascular predictors for SF in our study. Low baseline BCVA, the presence of IRF and SHRM, however, are easily identifiable baseline parameters indicating increased risk.
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spelling pubmed-87419272022-01-10 Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration Roberts, Philipp K. Schranz, Markus Motschi, Alice Desissaire, Sylvia Hacker, Valentin Pircher, Michael Sacu, Stefan Buehl, Wolf Hitzenberger, Christoph K. Schmidt-Erfurth, Ursula M. Sci Rep Article To find baseline predictors for subretinal fibrosis (SF) in neovascular age-related macular degeneration (nAMD). Forty-five eyes of 45 participants with treatment-naïve nAMD were consecutively enrolled and treated according to a standardized treat-and-extend protocol. Spectral-domain optical coherence tomography (OCT), color fundus photography and fluorescein angiography as well as novel imaging modalities polarization-sensitive OCT and OCT angiography (OCTA) were performed to detect SF after 1 year and find baseline predictors for SF development. Baseline OCTA scans were evaluated for quantitative features such as lesion area, vessel area, vessel junctions, vessel length, vessel endpoints and mean lacunarity. Additionally, the type of macular neovascularization, the presence of subretinal fluid, intraretinal fluid (IRF), subretinal hyperreflective material (SHRM), retinal hemorrhage as well as best-corrected visual acuity (BCVA) were evaluated. After 12 months 8 eyes (18%) developed SF. Eyes with SF had worse baseline BCVA (p = .001) and a higher prevalence of IRF (p = .014) and SHRM at baseline (p = .017). There was no significant difference in any of the evaluated quantitative OCTA parameters (p > .05) between eyes with and without SF. There were no quantitative baseline microvascular predictors for SF in our study. Low baseline BCVA, the presence of IRF and SHRM, however, are easily identifiable baseline parameters indicating increased risk. Nature Publishing Group UK 2022-01-07 /pmc/articles/PMC8741927/ /pubmed/34996934 http://dx.doi.org/10.1038/s41598-021-03716-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Roberts, Philipp K.
Schranz, Markus
Motschi, Alice
Desissaire, Sylvia
Hacker, Valentin
Pircher, Michael
Sacu, Stefan
Buehl, Wolf
Hitzenberger, Christoph K.
Schmidt-Erfurth, Ursula M.
Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
title Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
title_full Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
title_fullStr Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
title_full_unstemmed Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
title_short Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
title_sort baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741927/
https://www.ncbi.nlm.nih.gov/pubmed/34996934
http://dx.doi.org/10.1038/s41598-021-03716-8
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