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Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid leukemia (AML), cholangiocarcinoma, melanoma, and thyroid carcinoma. The pathobiological effects of these mutations vary considerably, impeding the i...

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Detalles Bibliográficos
Autores principales:	Schulten, Hans-Juergen, Al-Adwani, Fatima, Saddeq, Haneen A. Bin, Alkhatabi, Heba, Alganmi, Nofe, Karim, Sajjad, Hussein, Deema, Al-Ghamdi, Khalid B., Jamal, Awatif, Al-Maghrabi, Jaudah, Al-Qahtani, Mohammed H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741954/ https://www.ncbi.nlm.nih.gov/pubmed/34997121 http://dx.doi.org/10.1038/s41598-021-04214-7

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