Cargando…

Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid leukemia (AML), cholangiocarcinoma, melanoma, and thyroid carcinoma. The pathobiological effects of these mutations vary considerably, impeding the i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schulten, Hans-Juergen, Al-Adwani, Fatima, Saddeq, Haneen A. Bin, Alkhatabi, Heba, Alganmi, Nofe, Karim, Sajjad, Hussein, Deema, Al-Ghamdi, Khalid B., Jamal, Awatif, Al-Maghrabi, Jaudah, Al-Qahtani, Mohammed H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741954/ https://www.ncbi.nlm.nih.gov/pubmed/34997121 http://dx.doi.org/10.1038/s41598-021-04214-7

Ejemplares similares

Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression
por: Schulten, Hans-Juergen, et al.
Publicado: (2016)

Prototype Development of an Expert System of Computerized Clinical Guidelines for COVID-19 Diagnosis and Management in Saudi Arabia
por: Banjar, Haneen Reda, et al.
Publicado: (2020)

Comprehensive molecular biomarker identification in breast cancer brain metastases
por: Schulten, Hans-Juergen, et al.
Publicado: (2017)

Nodular goiter and hyperplastic lesion of the thyroid share common deregulated expression profiles
por: Subhi, Ohoud, et al.
Publicado: (2014)

Brain and bone metastasis from malignant thyroid carcinomas originating in western Saudi Arabia
por: Baghallab, Ibtisam, et al.
Publicado: (2014)

Identification of Novel Diagnostic and Prognostic Gene Signature Biomarkers for Breast Cancer Using Artificial Intelligence and Machine Learning Assisted Transcriptomics Analysis
por: Mirza, Zeenat, et al.
Publicado: (2023)

Association of single nucleotide polymorphisms in FOXE1 and pre-MIR146A with papillary thyroid carcinoma
por: Bagatian, Nadia, et al.
Publicado: (2014)

Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines
por: Khan, Ishaq, et al.
Publicado: (2017)

Composite Lymphoma’s Ability to Adapt and Change Through Plasticity: A Case Report and Literature Review
por: Al-Maghrabi, Haneen, et al.
Publicado: (2023)

Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis
por: Subhi, Ohoud, et al.
Publicado: (2020)

Evaluation of an optimized germline exomes pipeline using BWA-MEM2 and Dragen-GATK tools
por: Alganmi, Nofe, et al.
Publicado: (2023)

High-density microarray expression profiling in conventional papillary thyroid carcinomas with versus without a BRAF mutation
por: Alotibi, Reem, et al.
Publicado: (2014)

Effect of BRAF mutational status on expression profiles in conventional papillary thyroid carcinomas
por: Schulten, Hans-Juergen, et al.
Publicado: (2015)

Two Novel Homozygous HPS6 Mutations (Double Mutant) Identified by Whole-Exome Sequencing in a Saudi Consanguineous Family Suspected for Oculocutaneous Albinism
por: Karim, Sajjad, et al.
Publicado: (2021)

Desmoplastic Small Round Cell Tumor of Pancreatic Origin in a Young Child: A Case Report and Review of Literature
por: Saleh, Daniyah, et al.
Publicado: (2020)

Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer
por: Hakamy, Sahar, et al.
Publicado: (2021)

Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2021)

Frequent microdeletions in conventional papillary thyroid carcinoma detected by high-density oligonucleotide microarrays
por: Al-Ahmadi, Alaa, et al.
Publicado: (2014)

Long-Term Remission of a Spinal Atypical Teratoid Rhabdoid Tumor in Response to Intensive Multimodal Therapy
por: Refai, Fahd, et al.
Publicado: (2019)

Pulmonary alveolar microlithiasis: A report of two unique cases
por: Al-Maghrabi, Haneen, et al.
Publicado: (2019)

Atypical Presentation of Giant Mandibular Aneurysmal Bone Cyst with Cemento-Ossifying Fibroma Mimicking Sarcoma
por: Al-Maghrabi, Haneen, et al.
Publicado: (2019)

Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid
por: Schulten, Hans-Juergen, et al.
Publicado: (2015)

Initial characterization of drug resistant cancer stem cells isolated from primary brain tumors (astrocytoma) cell lines generated from Saudi patients
por: Khan, Ishaq, et al.
Publicado: (2014)

Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics
por: Mirza, Zeenat, et al.
Publicado: (2015)

Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma
por: Al-Maghrabi, Haneen, et al.
Publicado: (2020)

BRAF mutations in thyroid tumors from an ethnically diverse group
por: Schulten, Hans-Juergen, et al.
Publicado: (2012)

IDH1/IDH2 Inhibition in Acute Myeloid Leukemia
por: Cerchione, Claudio, et al.
Publicado: (2021)

The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma
por: Al Ghamdi, Doaa, et al.
Publicado: (2015)

Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma
por: Krell, Daniel, et al.
Publicado: (2011)

Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience
por: Cho, Uiju, et al.
Publicado: (2021)

High-density expression profiling of renal cell carcinomas from Saudi Arabia: a preliminary study
por: Karim, Sajjad, et al.
Publicado: (2014)

Mutant IDH1 is required for IDH1 mutated tumor cell growth
por: Jin, Genglin, et al.
Publicado: (2012)

IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
por: DiNardo, Courtney D, et al.
Publicado: (2015)

IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
por: Mondesir, Johanna, et al.
Publicado: (2016)

IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution
por: Rodriguez, Erika F., et al.
Publicado: (2020)

Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM
por: Pasquini, Luca, et al.
Publicado: (2021)

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL
por: Simonin, Mathieu, et al.
Publicado: (2021)

Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report
por: Haider, Ali S., et al.
Publicado: (2023)

Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia
por: Al-Maghrabi, Jaudah, et al.
Publicado: (2023)

Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model
por: Clausing, Maximilian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u9m8jf0n6heu0mjn1aiu1ieqj5