BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level

BIX01294 (BIX), an inhibitor of the G9a histone methyltransferase, has been reported to have antitumor activity against a variety of cancers. However, the molecular mechanisms underlying its anticancer effects, particularly those against lung cancer, remain unclear. Here, we report that BIX induces...

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Detalles Bibliográficos
Autores principales: Kim, Ji Hye, Kim, Jongwook, Im, Se Seul, Lee, Ji Hyeon, Hwang, Sein, Chang, Eun-Ju, Shin, Dong-Myung, Rho, Jin Kyung, Son, Jaekyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741967/
https://www.ncbi.nlm.nih.gov/pubmed/34876693
http://dx.doi.org/10.1038/s12276-021-00715-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741967/
https://www.ncbi.nlm.nih.gov/pubmed/34876693
http://dx.doi.org/10.1038/s12276-021-00715-7

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