Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

Uveal melanoma (UM) is an aggressive intra-ocular cancer with a strong tendency to metastasize. Metastatic UM is associated with mutations in BAP1 and SF3B1, however only little is known about the epigenetic modifications that arise in metastatic UM. In this study we aim to unravel epigenetic change...

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Detalles Bibliográficos
Autores principales: Smit, Kyra N., Boers, Ruben, Vaarwater, Jolanda, Boers, Joachim, Brands, Tom, Mensink, Hanneke, Verdijk, Robert M., van IJcken, Wilfred F. J., Gribnau, Joost, de Klein, Annelies, Kilic, Emine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742000/
https://www.ncbi.nlm.nih.gov/pubmed/34997020
http://dx.doi.org/10.1038/s41598-021-03964-8

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