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Advances in the study of CDC42 in the female reproductive system

CDC42 is a member of the Rho‐GTPase family and is involved in a variety of cellular functions including regulation of cell cycle progression, constitution of the actin backbone and membrane transport. In particular, CDC42 plays a key role in the establishment of polarity in female vertebrate oocytes...

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Autores principales: Mei, Qiaojuan, Li, Huiying, Liu, Yu, Wang, Xiaofei, Xiang, Wenpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742232/
https://www.ncbi.nlm.nih.gov/pubmed/34859585
http://dx.doi.org/10.1111/jcmm.17088
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author Mei, Qiaojuan
Li, Huiying
Liu, Yu
Wang, Xiaofei
Xiang, Wenpei
author_facet Mei, Qiaojuan
Li, Huiying
Liu, Yu
Wang, Xiaofei
Xiang, Wenpei
author_sort Mei, Qiaojuan
collection PubMed
description CDC42 is a member of the Rho‐GTPase family and is involved in a variety of cellular functions including regulation of cell cycle progression, constitution of the actin backbone and membrane transport. In particular, CDC42 plays a key role in the establishment of polarity in female vertebrate oocytes, and essential to this major regulatory role is its local occupation of specific regions of the cell to ensure that the contractile ring is assembled at the right time and place to ensure proper gametogenesis. The multifactor controlled ‘inactivation‐activation’ process of CDC42 also allows it to play an important role in the multilevel signalling network, and the synergistic regulation of multiple genes ensures maximum precision during gametogenesis. The purpose of this paper is to review the role of CDC42 in the control of gametogenesis and to explore its related mechanisms, with the aim of further understanding the great research potential of CDC42 in female vertebrate germ cells and its future clinical translation.
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spelling pubmed-87422322022-01-12 Advances in the study of CDC42 in the female reproductive system Mei, Qiaojuan Li, Huiying Liu, Yu Wang, Xiaofei Xiang, Wenpei J Cell Mol Med Reviews CDC42 is a member of the Rho‐GTPase family and is involved in a variety of cellular functions including regulation of cell cycle progression, constitution of the actin backbone and membrane transport. In particular, CDC42 plays a key role in the establishment of polarity in female vertebrate oocytes, and essential to this major regulatory role is its local occupation of specific regions of the cell to ensure that the contractile ring is assembled at the right time and place to ensure proper gametogenesis. The multifactor controlled ‘inactivation‐activation’ process of CDC42 also allows it to play an important role in the multilevel signalling network, and the synergistic regulation of multiple genes ensures maximum precision during gametogenesis. The purpose of this paper is to review the role of CDC42 in the control of gametogenesis and to explore its related mechanisms, with the aim of further understanding the great research potential of CDC42 in female vertebrate germ cells and its future clinical translation. John Wiley and Sons Inc. 2021-12-03 2022-01 /pmc/articles/PMC8742232/ /pubmed/34859585 http://dx.doi.org/10.1111/jcmm.17088 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Mei, Qiaojuan
Li, Huiying
Liu, Yu
Wang, Xiaofei
Xiang, Wenpei
Advances in the study of CDC42 in the female reproductive system
title Advances in the study of CDC42 in the female reproductive system
title_full Advances in the study of CDC42 in the female reproductive system
title_fullStr Advances in the study of CDC42 in the female reproductive system
title_full_unstemmed Advances in the study of CDC42 in the female reproductive system
title_short Advances in the study of CDC42 in the female reproductive system
title_sort advances in the study of cdc42 in the female reproductive system
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742232/
https://www.ncbi.nlm.nih.gov/pubmed/34859585
http://dx.doi.org/10.1111/jcmm.17088
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