The FusX TALE Base Editor (FusXTBE) for Rapid Mitochondrial DNA Programming of Human Cells In Vitro and Zebrafish Disease Models In Vivo

Functional analyses of mitochondria have been hampered by few effective approaches to manipulate mitochondrial DNA (mtDNA) and a lack of existing animal models. Recently a TALE-derived base editor was shown to induce C-to-T (or G-to-A) sequence changes in mtDNA. We report here the FusX TALE Base Edi...

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Detalles Bibliográficos
Autores principales: Sabharwal, Ankit, Kar, Bibekananda, Restrepo-Castillo, Santiago, Holmberg, Shannon R., Mathew, Neal D., Kendall, Benjamin Luke, Cotter, Ryan P., WareJoncas, Zachary, Seiler, Christoph, Nakamaru-Ogiso, Eiko, Clark, Karl J., Ekker, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742272/
https://www.ncbi.nlm.nih.gov/pubmed/34847747
http://dx.doi.org/10.1089/crispr.2021.0061

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