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The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

BACKGROUND AND AIM: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder...

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Autores principales: Mirinezhad, Mohammad Reza, Ghazizadeh, Hamideh, Aghsizadeh, Maliheh, Zamiri Bidary, Mohammad, Naghipour, Alireza, Hasanzadeh, Elahe, Yaghooti-Khorasani, Mahdiyeh, Ebrahimi Dabagh, Ali, Moghadam, Mohammad Reza Shadmand Foumani, Sheikh Andalibi, Nazanin, Naseri Far, Zeynab, Esmaily, Habibollah, Ferns, Gordon A., Hamzehloei, Tayebeh, Pasdar, Alireza, Ghayour-Mobarhan, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742392/
https://www.ncbi.nlm.nih.gov/pubmed/34996442
http://dx.doi.org/10.1186/s12905-021-01550-8
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author Mirinezhad, Mohammad Reza
Ghazizadeh, Hamideh
Aghsizadeh, Maliheh
Zamiri Bidary, Mohammad
Naghipour, Alireza
Hasanzadeh, Elahe
Yaghooti-Khorasani, Mahdiyeh
Ebrahimi Dabagh, Ali
Moghadam, Mohammad Reza Shadmand Foumani
Sheikh Andalibi, Nazanin
Naseri Far, Zeynab
Esmaily, Habibollah
Ferns, Gordon A.
Hamzehloei, Tayebeh
Pasdar, Alireza
Ghayour-Mobarhan, Majid
author_facet Mirinezhad, Mohammad Reza
Ghazizadeh, Hamideh
Aghsizadeh, Maliheh
Zamiri Bidary, Mohammad
Naghipour, Alireza
Hasanzadeh, Elahe
Yaghooti-Khorasani, Mahdiyeh
Ebrahimi Dabagh, Ali
Moghadam, Mohammad Reza Shadmand Foumani
Sheikh Andalibi, Nazanin
Naseri Far, Zeynab
Esmaily, Habibollah
Ferns, Gordon A.
Hamzehloei, Tayebeh
Pasdar, Alireza
Ghayour-Mobarhan, Majid
author_sort Mirinezhad, Mohammad Reza
collection PubMed
description BACKGROUND AND AIM: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. METHODS: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. RESULTS: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). CONCLUSION: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.
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spelling pubmed-87423922022-01-10 The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study Mirinezhad, Mohammad Reza Ghazizadeh, Hamideh Aghsizadeh, Maliheh Zamiri Bidary, Mohammad Naghipour, Alireza Hasanzadeh, Elahe Yaghooti-Khorasani, Mahdiyeh Ebrahimi Dabagh, Ali Moghadam, Mohammad Reza Shadmand Foumani Sheikh Andalibi, Nazanin Naseri Far, Zeynab Esmaily, Habibollah Ferns, Gordon A. Hamzehloei, Tayebeh Pasdar, Alireza Ghayour-Mobarhan, Majid BMC Womens Health Research BACKGROUND AND AIM: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. METHODS: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. RESULTS: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). CONCLUSION: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD. BioMed Central 2022-01-07 /pmc/articles/PMC8742392/ /pubmed/34996442 http://dx.doi.org/10.1186/s12905-021-01550-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mirinezhad, Mohammad Reza
Ghazizadeh, Hamideh
Aghsizadeh, Maliheh
Zamiri Bidary, Mohammad
Naghipour, Alireza
Hasanzadeh, Elahe
Yaghooti-Khorasani, Mahdiyeh
Ebrahimi Dabagh, Ali
Moghadam, Mohammad Reza Shadmand Foumani
Sheikh Andalibi, Nazanin
Naseri Far, Zeynab
Esmaily, Habibollah
Ferns, Gordon A.
Hamzehloei, Tayebeh
Pasdar, Alireza
Ghayour-Mobarhan, Majid
The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study
title The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study
title_full The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study
title_fullStr The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study
title_full_unstemmed The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study
title_short The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study
title_sort relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from mashad cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742392/
https://www.ncbi.nlm.nih.gov/pubmed/34996442
http://dx.doi.org/10.1186/s12905-021-01550-8
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