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ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

BACKGROUND: Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have not yielded success. Metabolic reprogramming is a key cancer hallmark and confers several tumor phenotypes including chem...

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Detalles Bibliográficos
Autores principales:	Dong, Shuohui, Liang, Shuo, Cheng, Zhiqiang, Zhang, Xiang, Luo, Li, Li, Linchuan, Zhang, Wenjie, Li, Songhan, Xu, Qian, Zhong, Mingwei, Zhu, Jiankang, Zhang, Guangyong, Hu, Sanyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742403/ https://www.ncbi.nlm.nih.gov/pubmed/34998404 http://dx.doi.org/10.1186/s13046-021-02229-6

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