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Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients

BACKGROUND/AIM: Biomarkers are useful for diagnosing infection and sepsis in adults, but data are limited in elderly patients. Furthermore, clinical symptoms of infection in elderly patients are usually atypical or unclear. We aimed to assess the usefulness of PCT, CRP, and WBC in distinguishing eld...

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Autores principales: ZİNCİRCİOĞLU, Çiler, ROLLAS, Kazım, GÜLDOĞAN, Işıl Köse, SARITAŞ, Aykut, ÖZKARAKAŞ, Hüseyin, ERSAN, Gürsel, ŞENOĞLU, Nimet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742470/
https://www.ncbi.nlm.nih.gov/pubmed/34344141
http://dx.doi.org/10.3906/sag-2007-268
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author ZİNCİRCİOĞLU, Çiler
ROLLAS, Kazım
GÜLDOĞAN, Işıl Köse
SARITAŞ, Aykut
ÖZKARAKAŞ, Hüseyin
ERSAN, Gürsel
ŞENOĞLU, Nimet
author_facet ZİNCİRCİOĞLU, Çiler
ROLLAS, Kazım
GÜLDOĞAN, Işıl Köse
SARITAŞ, Aykut
ÖZKARAKAŞ, Hüseyin
ERSAN, Gürsel
ŞENOĞLU, Nimet
author_sort ZİNCİRCİOĞLU, Çiler
collection PubMed
description BACKGROUND/AIM: Biomarkers are useful for diagnosing infection and sepsis in adults, but data are limited in elderly patients. Furthermore, clinical symptoms of infection in elderly patients are usually atypical or unclear. We aimed to assess the usefulness of PCT, CRP, and WBC in distinguishing elderly patients infected with sepsis from infected without sepsis and those with no-infection. We also aimed to find a cut-off value for diagnosing sepsis and infection without sepsis in elderly critically ill patients. MATERIALS AND METHODS: In this single-center and prospective observational study, patients older than 65 years were enrolled. Serum levels of PCT, CRP, and WBC were measured within 24 h. Patients were allocated into sepsis (S), infected without sepsis (IWS), and no-infection (NI) groups. Data were analyzed with Mann–Whitney U test and Kruskal–Wallis test. RESULTS: We analyzed 188 patients with a mean age of 77.05 ± 7.4 in the study; 95 (50.5%) of them were women. Sixty-four (34%) of whom were classified as IWS, 29 (15%) as S, and 95 (50.5%) as NI group. There were significant differences in the PCT, CRP levels between the IWS and NI, S and NI (p < 0.001, p < 0.001, p < 0.001, p < 0.01, respectively). The PCT levels were significantly different when the NI group was compared to IWS (p < 0.001) and S (p < 0.001) groups. The CRP levels were also different when the NI group was compared to both IWS (p < 0.001) and S (p < 0.001). The PCT cut-off values were 0.485 μ/L and 1.245 μg/L for the discrimination of patients with IWS and S, respectively. The cut-off values of CRP level were 59.45 mg/L and 57.50 mg/L for infected without sepsis and sepsis, respectively.  CONCLUSION: PCT was found to be a more valuable marker than CRP and WBC for the discrimination of elderly patients with infected without sepsis and sepsis.
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spelling pubmed-87424702022-01-20 Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients ZİNCİRCİOĞLU, Çiler ROLLAS, Kazım GÜLDOĞAN, Işıl Köse SARITAŞ, Aykut ÖZKARAKAŞ, Hüseyin ERSAN, Gürsel ŞENOĞLU, Nimet Turk J Med Sci Article BACKGROUND/AIM: Biomarkers are useful for diagnosing infection and sepsis in adults, but data are limited in elderly patients. Furthermore, clinical symptoms of infection in elderly patients are usually atypical or unclear. We aimed to assess the usefulness of PCT, CRP, and WBC in distinguishing elderly patients infected with sepsis from infected without sepsis and those with no-infection. We also aimed to find a cut-off value for diagnosing sepsis and infection without sepsis in elderly critically ill patients. MATERIALS AND METHODS: In this single-center and prospective observational study, patients older than 65 years were enrolled. Serum levels of PCT, CRP, and WBC were measured within 24 h. Patients were allocated into sepsis (S), infected without sepsis (IWS), and no-infection (NI) groups. Data were analyzed with Mann–Whitney U test and Kruskal–Wallis test. RESULTS: We analyzed 188 patients with a mean age of 77.05 ± 7.4 in the study; 95 (50.5%) of them were women. Sixty-four (34%) of whom were classified as IWS, 29 (15%) as S, and 95 (50.5%) as NI group. There were significant differences in the PCT, CRP levels between the IWS and NI, S and NI (p < 0.001, p < 0.001, p < 0.001, p < 0.01, respectively). The PCT levels were significantly different when the NI group was compared to IWS (p < 0.001) and S (p < 0.001) groups. The CRP levels were also different when the NI group was compared to both IWS (p < 0.001) and S (p < 0.001). The PCT cut-off values were 0.485 μ/L and 1.245 μg/L for the discrimination of patients with IWS and S, respectively. The cut-off values of CRP level were 59.45 mg/L and 57.50 mg/L for infected without sepsis and sepsis, respectively.  CONCLUSION: PCT was found to be a more valuable marker than CRP and WBC for the discrimination of elderly patients with infected without sepsis and sepsis. The Scientific and Technological Research Council of Turkey 2021-10-21 /pmc/articles/PMC8742470/ /pubmed/34344141 http://dx.doi.org/10.3906/sag-2007-268 Text en Copyright © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
ZİNCİRCİOĞLU, Çiler
ROLLAS, Kazım
GÜLDOĞAN, Işıl Köse
SARITAŞ, Aykut
ÖZKARAKAŞ, Hüseyin
ERSAN, Gürsel
ŞENOĞLU, Nimet
Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients
title Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients
title_full Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients
title_fullStr Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients
title_full_unstemmed Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients
title_short Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients
title_sort diagnostic value of procalcitonin and c reactive protein for infection and sepsis in elderly patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742470/
https://www.ncbi.nlm.nih.gov/pubmed/34344141
http://dx.doi.org/10.3906/sag-2007-268
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