Sex Specific Effects of Prunella vulgaris on Longevity Regulation

The sudden outbreak of COVID-19 in over 200 countries globally, brought serious effects on our daily lives. Traditional Chinese Medicine (TCM) in combination with regional characteristics has achieved remarkable results in China. Prunella vulgaris is one of the ingredients of commercially available canned Chinese herbal tea which demonstrated lifespan extending effect on Drosophila in our previous study, whereas it is unknown which ingredients contribute to it. This study used Drosophila as the model to explore whether Prunella vulgaris is the component taking effect on Drosophila longevity. Results showed that Prunella vulgaris can extend the lifespan of female flies by 10.42%, and improve their endurance under heat stress by 18.46%. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11130-022-00950-x.