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Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk scores (wGRSs) based on common variants explain only 30–35%. Rare va...

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Detalles Bibliográficos
Autores principales:	El‐Boraie, Ahmed, Tanner, Julie‐Anne, Zhu, Andy Z.X., Claw, Katrina G., Prasad, Bhagwat, Schuetz, Erin G., Thummel, Kenneth E., Fukunaga, Koya, Mushiroda, Taisei, Kubo, Michiaki, Benowitz, Neal L., Lerman, Caryn, Tyndale, Rachel F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742641/ https://www.ncbi.nlm.nih.gov/pubmed/34476898 http://dx.doi.org/10.1111/cts.13135

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