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Processing of Viral DNA Ends Channels the HIV-1 Integration Reaction to Concerted Integration
Retroviral DNA made by reverse transcription is blunt-ended, and the viral integrase protein must remove two nucleotides from each 3′ end prior to integration into chromosomal DNA. Under most reaction conditions for integration in vitro, the majority of the reaction products are “half-site” products...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742673/ https://www.ncbi.nlm.nih.gov/pubmed/15958388 http://dx.doi.org/10.1074/jbc.M505367200 |