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HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

A noninvasive test to discriminate indolent prostate cancers from lethal ones would focus treatment where necessary while reducing overtreatment. We exploited the known activity of heat shock protein 90 (Hsp90) as a chaperone critical for the function of numerous oncogenic drivers, including the and...

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Detalles Bibliográficos
Autores principales:	Osada, Takuya, Crosby, Erika J., Kaneko, Kensuke, Snyder, Joshua C., Ginzel, Joshua D., Acharya, Chaitanya R., Yang, Xiao-Yi, Polascik, Thomas J., Spasojevic, Ivan, Nelson, Rendon C., Hobeika, Amy, Hartman, Zachary C., Neckers, Leonard M., Rogatko, Andre, Hughes, Philip F., Huang, Jiaoti, Morse, Michael A., Haystead, Timothy, Lyerly, H. Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742774/ https://www.ncbi.nlm.nih.gov/pubmed/34675120 http://dx.doi.org/10.1158/1535-7163.MCT-21-0334

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