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Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat

Recurrent laryngeal afferent fibers are primarily responsible for cough in response to mechanical or chemical stimulation of the upper trachea and larynx in the guinea pig. Lower airway slowly adapting receptors have been proposed to have a permissive effect on the cough reflex. We hypothesized that...

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Autores principales: Shen, Tabitha Y., Pertzborn, Matthew C., Rose, Melanie J., Musselwhite, M. Nicholas, Davenport, Paul W., Bolser, Donald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742786/
https://www.ncbi.nlm.nih.gov/pubmed/34678475
http://dx.doi.org/10.1016/j.resp.2021.103805
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author Shen, Tabitha Y.
Pertzborn, Matthew C.
Rose, Melanie J.
Musselwhite, M. Nicholas
Davenport, Paul W.
Bolser, Donald C.
author_facet Shen, Tabitha Y.
Pertzborn, Matthew C.
Rose, Melanie J.
Musselwhite, M. Nicholas
Davenport, Paul W.
Bolser, Donald C.
author_sort Shen, Tabitha Y.
collection PubMed
description Recurrent laryngeal afferent fibers are primarily responsible for cough in response to mechanical or chemical stimulation of the upper trachea and larynx in the guinea pig. Lower airway slowly adapting receptors have been proposed to have a permissive effect on the cough reflex. We hypothesized that vagotomy below the recurrent laryngeal nerve branch would depress mechanically or chemically induced cough. In anesthetized, bilaterally thoracotomized, artificially ventilated cats, thoracic vagotomy nearly eliminated cough induced by mechanical stimulation of the intrathoracic airway, significantly depressed mechanically stimulated laryngeal cough, and eliminated capsaicin-induced cough. These results support an important role of lower airway sensory feedback in the production of tracheobronchial and laryngeal cough in the cat. Further, at least some of this feedback is due to excitation from pulmonary volume-sensitive sensory receptors.
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spelling pubmed-87427862022-02-01 Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat Shen, Tabitha Y. Pertzborn, Matthew C. Rose, Melanie J. Musselwhite, M. Nicholas Davenport, Paul W. Bolser, Donald C. Respir Physiol Neurobiol Article Recurrent laryngeal afferent fibers are primarily responsible for cough in response to mechanical or chemical stimulation of the upper trachea and larynx in the guinea pig. Lower airway slowly adapting receptors have been proposed to have a permissive effect on the cough reflex. We hypothesized that vagotomy below the recurrent laryngeal nerve branch would depress mechanically or chemically induced cough. In anesthetized, bilaterally thoracotomized, artificially ventilated cats, thoracic vagotomy nearly eliminated cough induced by mechanical stimulation of the intrathoracic airway, significantly depressed mechanically stimulated laryngeal cough, and eliminated capsaicin-induced cough. These results support an important role of lower airway sensory feedback in the production of tracheobronchial and laryngeal cough in the cat. Further, at least some of this feedback is due to excitation from pulmonary volume-sensitive sensory receptors. 2021-10-19 2022-02 /pmc/articles/PMC8742786/ /pubmed/34678475 http://dx.doi.org/10.1016/j.resp.2021.103805 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Shen, Tabitha Y.
Pertzborn, Matthew C.
Rose, Melanie J.
Musselwhite, M. Nicholas
Davenport, Paul W.
Bolser, Donald C.
Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
title Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
title_full Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
title_fullStr Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
title_full_unstemmed Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
title_short Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
title_sort influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742786/
https://www.ncbi.nlm.nih.gov/pubmed/34678475
http://dx.doi.org/10.1016/j.resp.2021.103805
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