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Protein nanoparticles directed cancer imaging and therapy

Cancer has been a serious threat to human health. Among drug delivery carriers, protein nanoparticles are unique because of their mild and environmentally friendly preparation methods. They also inherit desired characteristics from natural proteins, such as biocompatibility and biodegradability. The...

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Detalles Bibliográficos
Autores principales: Miao, Yao, Yang, Tao, Yang, Shuxu, Yang, Mingying, Mao, Chuanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742799/
https://www.ncbi.nlm.nih.gov/pubmed/34997888
http://dx.doi.org/10.1186/s40580-021-00293-4
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author Miao, Yao
Yang, Tao
Yang, Shuxu
Yang, Mingying
Mao, Chuanbin
author_facet Miao, Yao
Yang, Tao
Yang, Shuxu
Yang, Mingying
Mao, Chuanbin
author_sort Miao, Yao
collection PubMed
description Cancer has been a serious threat to human health. Among drug delivery carriers, protein nanoparticles are unique because of their mild and environmentally friendly preparation methods. They also inherit desired characteristics from natural proteins, such as biocompatibility and biodegradability. Therefore, they have solved some problems inherent to inorganic nanocarriers such as poor biocompatibility. Also, the surface groups and cavity of protein nanoparticles allow for easy surface modification and drug loading. Besides, protein nanoparticles can be combined with inorganic nanoparticles or contrast agents to form multifunctional theranostic platforms. This review introduces representative protein nanoparticles applicable in cancer theranostics, including virus-like particles, albumin nanoparticles, silk protein nanoparticles, and ferritin nanoparticles. It also describes the common methods for preparing them. It then critically analyzes the use of a variety of protein nanoparticles in improved cancer imaging and therapy.
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spelling pubmed-87427992022-01-20 Protein nanoparticles directed cancer imaging and therapy Miao, Yao Yang, Tao Yang, Shuxu Yang, Mingying Mao, Chuanbin Nano Converg Review Cancer has been a serious threat to human health. Among drug delivery carriers, protein nanoparticles are unique because of their mild and environmentally friendly preparation methods. They also inherit desired characteristics from natural proteins, such as biocompatibility and biodegradability. Therefore, they have solved some problems inherent to inorganic nanocarriers such as poor biocompatibility. Also, the surface groups and cavity of protein nanoparticles allow for easy surface modification and drug loading. Besides, protein nanoparticles can be combined with inorganic nanoparticles or contrast agents to form multifunctional theranostic platforms. This review introduces representative protein nanoparticles applicable in cancer theranostics, including virus-like particles, albumin nanoparticles, silk protein nanoparticles, and ferritin nanoparticles. It also describes the common methods for preparing them. It then critically analyzes the use of a variety of protein nanoparticles in improved cancer imaging and therapy. Springer Singapore 2022-01-08 /pmc/articles/PMC8742799/ /pubmed/34997888 http://dx.doi.org/10.1186/s40580-021-00293-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Miao, Yao
Yang, Tao
Yang, Shuxu
Yang, Mingying
Mao, Chuanbin
Protein nanoparticles directed cancer imaging and therapy
title Protein nanoparticles directed cancer imaging and therapy
title_full Protein nanoparticles directed cancer imaging and therapy
title_fullStr Protein nanoparticles directed cancer imaging and therapy
title_full_unstemmed Protein nanoparticles directed cancer imaging and therapy
title_short Protein nanoparticles directed cancer imaging and therapy
title_sort protein nanoparticles directed cancer imaging and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742799/
https://www.ncbi.nlm.nih.gov/pubmed/34997888
http://dx.doi.org/10.1186/s40580-021-00293-4
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