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Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions

Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypot...

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Detalles Bibliográficos
Autores principales: Al-hussaniy, Hany Akeel, Alburghaif, Ali Hikmate, Naji, Meena Akeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742898/
https://www.ncbi.nlm.nih.gov/pubmed/35027962
http://dx.doi.org/10.25122/jml-2021-0153
Descripción
Sumario:Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypothalamus and the feeding center in the ventral tegmental area. It also plays a role in regulatory aspects other than fat cells, such as obesity, which is linked to a loss of sensitivity of leptin receptors, resulting in an inability to produce satiety and an increase in food intake. Moreover, leptin plays a part in lactation, bone density, the immune system, diabetes treatments, and hypertriglyceridemia. The latest studies in leptin suggest that an analog of leptin may treat DM and hypertriglyceridemia. Further research should be conducted on the effectiveness of leptin on other related diseases.