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Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions
Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypot...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742898/ https://www.ncbi.nlm.nih.gov/pubmed/35027962 http://dx.doi.org/10.25122/jml-2021-0153 |
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author | Al-hussaniy, Hany Akeel Alburghaif, Ali Hikmate Naji, Meena Akeel |
author_facet | Al-hussaniy, Hany Akeel Alburghaif, Ali Hikmate Naji, Meena Akeel |
author_sort | Al-hussaniy, Hany Akeel |
collection | PubMed |
description | Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypothalamus and the feeding center in the ventral tegmental area. It also plays a role in regulatory aspects other than fat cells, such as obesity, which is linked to a loss of sensitivity of leptin receptors, resulting in an inability to produce satiety and an increase in food intake. Moreover, leptin plays a part in lactation, bone density, the immune system, diabetes treatments, and hypertriglyceridemia. The latest studies in leptin suggest that an analog of leptin may treat DM and hypertriglyceridemia. Further research should be conducted on the effectiveness of leptin on other related diseases. |
format | Online Article Text |
id | pubmed-8742898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-87428982022-01-12 Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions Al-hussaniy, Hany Akeel Alburghaif, Ali Hikmate Naji, Meena Akeel J Med Life Review Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypothalamus and the feeding center in the ventral tegmental area. It also plays a role in regulatory aspects other than fat cells, such as obesity, which is linked to a loss of sensitivity of leptin receptors, resulting in an inability to produce satiety and an increase in food intake. Moreover, leptin plays a part in lactation, bone density, the immune system, diabetes treatments, and hypertriglyceridemia. The latest studies in leptin suggest that an analog of leptin may treat DM and hypertriglyceridemia. Further research should be conducted on the effectiveness of leptin on other related diseases. Carol Davila University Press 2021 /pmc/articles/PMC8742898/ /pubmed/35027962 http://dx.doi.org/10.25122/jml-2021-0153 Text en ©2021 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Al-hussaniy, Hany Akeel Alburghaif, Ali Hikmate Naji, Meena Akeel Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
title | Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
title_full | Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
title_fullStr | Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
title_full_unstemmed | Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
title_short | Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
title_sort | leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742898/ https://www.ncbi.nlm.nih.gov/pubmed/35027962 http://dx.doi.org/10.25122/jml-2021-0153 |
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